Benzyl 4-(2,3-dichlorophenyl)-1,3,6-trimethyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Base Information

• Chemical Name: Benzyl 4-(2,3-dichlorophenyl)-1,3,6-trimethyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
• CAS No.: 250649-42-4
• Molecular Formula: C₂₁H₂₀Cl₂N₂O₃
• Molecular Weight: 419.307

Synonyms:Benzyl 4-(2,3-dichlorophenyl)-1,3,6-trimethyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Chemical Property of Benzyl 4-(2,3-dichlorophenyl)-1,3,6-trimethyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Chemical Property:

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Technology Process of Benzyl 4-(2,3-dichlorophenyl)-1,3,6-trimethyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

There total 3 articles about Benzyl 4-(2,3-dichlorophenyl)-1,3,6-trimethyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

dimethyl sulfate (77-78-1) + Benzyl 4-(2,3-dichlorophenyl)-1,6-dimethyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate (250649-08-2) → Benzyl 4-(2,3-dichlorophenyl)-1,3,6-trimethyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate (250649-42-4)

Guidance literature:

Benzyl 4-(2,3-dichlorophenyl)-1,6-dimethyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate; With sodium hydride; In toluene; at 70 ℃; for 0.5h;

dimethyl sulfate; In toluene; at 70 ℃; for 6h; Further stages.;

DOI:10.1039/b006372j

Reference yield:

benzyl acetoacetate (5396-89-4) → Benzyl 4-(2,3-dichlorophenyl)-1,3,6-trimethyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate (250649-42-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 93 percent / polyphosphate ester / tetrahydrofuran / 24 h / Heating

2.1: NaH / toluene / 0.5 h / 70 °C

2.2: 84 percent / toluene / 6 h / 70 °C

With polyphosphate ester; sodium hydride; In tetrahydrofuran; toluene; 1.1: Biginelli cyclocondensation;

DOI:10.1039/b006372j

Reference yield:

2,3-dichlorobenzylaldehyde (6334-18-5) → Benzyl 4-(2,3-dichlorophenyl)-1,3,6-trimethyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate (250649-42-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 93 percent / polyphosphate ester / tetrahydrofuran / 24 h / Heating

2.1: NaH / toluene / 0.5 h / 70 °C

2.2: 84 percent / toluene / 6 h / 70 °C

With polyphosphate ester; sodium hydride; In tetrahydrofuran; toluene; 1.1: Biginelli cyclocondensation;

DOI:10.1039/b006372j

upstream raw materials:

dimethyl sulfate

Benzyl 4-(2,3-dichlorophenyl)-1,6-dimethyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

benzyl acetoacetate

2,3-dichlorobenzylaldehyde

Downstream raw materials:

4-(2,3-Dichlorophenyl)-2-oxo-1,3,6-trimethyl-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid

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