(S)-4-(tert-Butyl-diphenyl-silanyloxy)-4-((S)-5-oxo-tetrahydro-furan-2-yl)-butyraldehyde

Base Information

Chemical Name:(S)-4-(tert-Butyl-diphenyl-silanyloxy)-4-((S)-5-oxo-tetrahydro-furan-2-yl)-butyraldehyde
CAS No.:182072-78-2
Molecular Formula:C₂₄H₃₀O₄Si
Molecular Weight:410.585
Hs Code.:

Synonyms:(S)-4-(tert-Butyl-diphenyl-silanyloxy)-4-((S)-5-oxo-tetrahydro-furan-2-yl)-butyraldehyde

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Chemical Property of (S)-4-(tert-Butyl-diphenyl-silanyloxy)-4-((S)-5-oxo-tetrahydro-furan-2-yl)-butyraldehyde

Chemical Property:

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Technology Process of (S)-4-(tert-Butyl-diphenyl-silanyloxy)-4-((S)-5-oxo-tetrahydro-furan-2-yl)-butyraldehyde

There total 11 articles about (S)-4-(tert-Butyl-diphenyl-silanyloxy)-4-((S)-5-oxo-tetrahydro-furan-2-yl)-butyraldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 181803-05-4
ethyl (4E)-8-benzyloxy-4-enoctanoate

: 182072-78-2
(S)-4-(tert-Butyl-diphenyl-silanyloxy)-4-((S)-5-oxo-tetrahydro-furan-2-yl)-butyraldehyde

Guidance literature:: Multi-step reaction with 6 steps

1: AD-mix-α, methanesulfonamide / 2-methyl-propan-2-ol; H2O / 24 h / 0 °C

2: 1.) aq. KOH, 2.) aq. HCl / 1.) MeOH

3: TsOH / CH₂Cl₂ / 1 h / Ambient temperature

4: imidazole / dimethylformamide / 16 h / Ambient temperature

5: H₂ / Pd/C (10percent) / methanol; propionic acid / 24 h

6: PCC, celite / CH₂Cl₂ / 2 h

With 1H-imidazole; hydrogenchloride; potassium hydroxide; AD-mix-α; methanesulfonamide; Celite; hydrogen; toluene-4-sulfonic acid; pyridinium chlorochromate; palladium on activated charcoal; In methanol; dichloromethane; water; propionic acid; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1021/jo961286m

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 182072-78-2
(S)-4-(tert-Butyl-diphenyl-silanyloxy)-4-((S)-5-oxo-tetrahydro-furan-2-yl)-butyraldehyde

Guidance literature:: Multi-step reaction with 3 steps

1: imidazole / dimethylformamide / 16 h / Ambient temperature

2: H₂ / Pd/C (10percent) / methanol; propionic acid / 24 h

3: PCC, celite / CH₂Cl₂ / 2 h

With 1H-imidazole; Celite; hydrogen; pyridinium chlorochromate; palladium on activated charcoal; In methanol; dichloromethane; propionic acid; N,N-dimethyl-formamide;
DOI:10.1021/jo961286m

Reference yield:

: 181803-09-8
(R)-5-((R)-4-Benzyloxy-1-hydroxy-butyl)-dihydro-furan-2-one

: 182072-78-2
(S)-4-(tert-Butyl-diphenyl-silanyloxy)-4-((S)-5-oxo-tetrahydro-furan-2-yl)-butyraldehyde

Guidance literature:: Multi-step reaction with 6 steps

1: PPh₃, DEAD / benzene / 16 h

2: 1.) aq. KOH, 2.) aq. HCl / 1.) EtOH, 16 h

3: TsOH / CH₂Cl₂ / 1 h / Ambient temperature

4: imidazole / dimethylformamide / 16 h / Ambient temperature

5: H₂ / Pd/C (10percent) / methanol; propionic acid / 24 h

6: PCC, celite / CH₂Cl₂ / 2 h

With 1H-imidazole; hydrogenchloride; potassium hydroxide; Celite; hydrogen; toluene-4-sulfonic acid; triphenylphosphine; pyridinium chlorochromate; diethylazodicarboxylate; palladium on activated charcoal; In methanol; dichloromethane; propionic acid; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jo961286m