Propargyl-PEG3-Ms

Base Information

• Chemical Name: Propargyl-PEG3-Ms
• CAS No.: 943726-01-0
• Molecular Formula: C₈H₁₄O₅S
• Molecular Weight: 222.262
• Mol file: 943726-01-0.mol

Synonyms:2-(2-(prop-2-yn-1-yloxy)ethoxy)ethyl methanesulfonate

Chemical Property of Propargyl-PEG3-Ms

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Propargyl-PEG3-Ms 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Description: Propargyl-PEG3-Ms is a crosslinking reagent with a propargyl group and a mesyl group. The propargyl group reacts with azide-bearing compounds or biomolecules in copper catalyzed Click Chemistry reactions.

Technology Process of Propargyl-PEG3-Ms

There total 1 articles about Propargyl-PEG3-Ms which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

diethylene glycol dimesylate (34604-52-9) + propargyl alcohol (107-19-7) → 2-(2-(prop-2-yn-1-yloxy)ethoxy)ethyl methanesulfonate (943726-01-0)

Guidance literature:

With sodium hydride; In tetrahydrofuran; mineral oil; at 0 ℃; Reflux; Inert atmosphere;

DOI:10.1021/jm5001453

Reference yield: 91.0%

2-(2-(prop-2-yn-1-yloxy)ethoxy)ethyl methanesulfonate (943726-01-0) + 1-(azidomethyl)-4-methoxybenzene (70978-37-9) → 4-[2-(2-fluoroethoxy)ethoxymethyl]-1-(4-methoxybenzyl)-1H-[1,2,3]triazole

Guidance literature:

2-(2-(prop-2-yn-1-yloxy)ethoxy)ethyl methanesulfonate; With tetrabutyl ammonium fluoride; In tert-butyl alcohol; at 100 ℃; for 0.333333h;

1-(azidomethyl)-4-methoxybenzene; With sodium L-ascorbate; In water; tert-butyl alcohol; at 20 ℃; for 0.5h; Further stages.;

DOI:10.1016/j.tetlet.2007.04.048

Reference yield: 73.0%

2-(2-(prop-2-yn-1-yloxy)ethoxy)ethyl methanesulfonate (943726-01-0) + 1-(3-azido-2,3-deoxy-5-O-trityl-β-D-erythro-pentofuranosyl)thymine (29706-84-1) → 4-[2-(2-fluoroethoxy)ethoxymethyl]-1-(5-O-trityl-2-deoxythymidin-3-yl)-1H-[1,2,3]triazole

Guidance literature:

2-(2-(prop-2-yn-1-yloxy)ethoxy)ethyl methanesulfonate; With tetrabutyl ammonium fluoride; In tert-butyl alcohol; at 100 ℃; for 0.333333h;

1-(3-azido-2,3-deoxy-5-O-trityl-β-D-erythro-pentofuranosyl)thymine; With copper(II) sulfate; sodium L-ascorbate; In water; tert-butyl alcohol; at 20 ℃; for 0.5h; Further stages.;

DOI:10.1016/j.tetlet.2007.04.048

upstream raw materials:

diethylene glycol dimesylate

propargyl alcohol

Downstream raw materials:

2-(2-((1-(3-methoxycarbonyl-4-methoxyphenyl)-1H-1,2,3-triazol-4-yl)methoxy)ethoxy)ethylmethanesulfonate

methyl 5-(4-((2-(2-fluoroethoxy)ethoxy)methyl)-1H-1,2,3-triazol-1-yl)-2-methoxybenzoate

5-(4-((2-(2-fluoroethoxy)ethoxy)methyl)-1H-1,2,3-triazol-1-yl)-2-methoxybenzoic acid

N-(4-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)butyl)-5-(4-((2-(2-fluoroethoxy)ethoxy)methyl)-1H-1,2,3-triazol-1-yl)-2-methoxybenzamide

Refernces

• 1、 Sirion, Uthaiwan,Kim, Hee Jun,Lee, Jae Hak,Seo, Jai Woong,Lee, Byoung Se,Lee, Sang Ju,Oh, Seung Jun,Chi, Dae Yoon. "An efficient F-18 labeling method for PET study: Huisgen 1,3-dipolar cycloaddition of bioactive substances and F-18-labeled compounds". . p. 3953 - 3957. Retrieved 2008/02/04.