methyl 5-(4-((2-(2-fluoroethoxy)ethoxy)methyl)-1H-1,2,3-triazol-1-yl)-2-methoxybenzoate

Base Information

Chemical Name:methyl 5-(4-((2-(2-fluoroethoxy)ethoxy)methyl)-1H-1,2,3-triazol-1-yl)-2-methoxybenzoate
CAS No.:1609429-14-2
Molecular Formula:C₁₆H₂₀FN₃O₅
Molecular Weight:353.35
Hs Code.:

Synonyms:methyl 5-(4-((2-(2-fluoroethoxy)ethoxy)methyl)-1H-1,2,3-triazol-1-yl)-2-methoxybenzoate

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Chemical Property of methyl 5-(4-((2-(2-fluoroethoxy)ethoxy)methyl)-1H-1,2,3-triazol-1-yl)-2-methoxybenzoate

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Technology Process of methyl 5-(4-((2-(2-fluoroethoxy)ethoxy)methyl)-1H-1,2,3-triazol-1-yl)-2-methoxybenzoate

There total 5 articles about methyl 5-(4-((2-(2-fluoroethoxy)ethoxy)methyl)-1H-1,2,3-triazol-1-yl)-2-methoxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1609429-21-1
2-(2-((1-(3-methoxycarbonyl-4-methoxyphenyl)-1H-1,2,3-triazol-4-yl)methoxy)ethoxy)ethylmethanesulfonate

: 1609429-14-2
methyl 5-(4-((2-(2-fluoroethoxy)ethoxy)methyl)-1H-1,2,3-triazol-1-yl)-2-methoxybenzoate

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; Reflux; Inert atmosphere;
DOI:10.1021/jm5001453

Reference yield:

: 119-30-2
2-hydroxy-5-iodobenzoic acid

: 1609429-14-2
methyl 5-(4-((2-(2-fluoroethoxy)ethoxy)methyl)-1H-1,2,3-triazol-1-yl)-2-methoxybenzoate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / acetone / Reflux; Inert atmosphere

2: sodium azide; copper(l) iodide; L-proline / N,N-dimethyl-formamide / 80 °C / Inert atmosphere

3: copper(II) sulfate; sodium L-ascorbate; bathophenanthrolinedispufonic acid disodium salt / water; N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

4: tetrabutyl ammonium fluoride / tetrahydrofuran / Reflux; Inert atmosphere

With copper(l) iodide; sodium azide; bathophenanthrolinedispufonic acid disodium salt; tetrabutyl ammonium fluoride; potassium carbonate; copper(II) sulfate; sodium L-ascorbate; L-proline; In tetrahydrofuran; water; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm5001453

Reference yield:

: 40757-09-3
methyl 2-methoxy-5-iodobenzoate

: 1609429-14-2
methyl 5-(4-((2-(2-fluoroethoxy)ethoxy)methyl)-1H-1,2,3-triazol-1-yl)-2-methoxybenzoate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium azide; copper(l) iodide; L-proline / N,N-dimethyl-formamide / 80 °C / Inert atmosphere

2: copper(II) sulfate; sodium L-ascorbate; bathophenanthrolinedispufonic acid disodium salt / water; N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

3: tetrabutyl ammonium fluoride / tetrahydrofuran / Reflux; Inert atmosphere

With copper(l) iodide; sodium azide; bathophenanthrolinedispufonic acid disodium salt; tetrabutyl ammonium fluoride; copper(II) sulfate; sodium L-ascorbate; L-proline; In tetrahydrofuran; water; N,N-dimethyl-formamide;
DOI:10.1021/jm5001453