3,5-dichloro-N-{4-[3-(4-chloro-3-methoxyphenyl)-4-(pyridin-4-yl)-1H-pyrazol-1-yl]phenyl}benzamide

Base Information

• Chemical Name: 3,5-dichloro-N-{4-[3-(4-chloro-3-methoxyphenyl)-4-(pyridin-4-yl)-1H-pyrazol-1-yl]phenyl}benzamide
• CAS No.: 1350473-82-3
• Molecular Formula: C₂₈H₁₉Cl₃N₄O₂
• Molecular Weight: 549.843

Synonyms:3,5-dichloro-N-{4-[3-(4-chloro-3-methoxyphenyl)-4-(pyridin-4-yl)-1H-pyrazol-1-yl]phenyl}benzamide

Chemical Property of 3,5-dichloro-N-{4-[3-(4-chloro-3-methoxyphenyl)-4-(pyridin-4-yl)-1H-pyrazol-1-yl]phenyl}benzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,5-dichloro-N-{4-[3-(4-chloro-3-methoxyphenyl)-4-(pyridin-4-yl)-1H-pyrazol-1-yl]phenyl}benzamide

There total 8 articles about 3,5-dichloro-N-{4-[3-(4-chloro-3-methoxyphenyl)-4-(pyridin-4-yl)-1H-pyrazol-1-yl]phenyl}benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

3,5-dichlorobenzoic acid (51-36-5) + 4-[3-(4-chloro-3-methoxyphenyl)-1-(4-aminophenyl)-1H-pyrazol-4-yl]pyridine (1350473-76-5) → 3,5-dichloro-N-{4-[3-(4-chloro-3-methoxyphenyl)-4-(pyridin-4-yl)-1H-pyrazol-1-yl]phenyl}benzamide (1350473-82-3)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 0 - 80 ℃; Inert atmosphere;

DOI:10.1016/j.ejmech.2011.08.013

Reference yield:

1-(4-chloro-3-methoxyphenyl)-2-(pyridin-4-yl)ethanone (342435-01-2) → 3,5-dichloro-N-{4-[3-(4-chloro-3-methoxyphenyl)-4-(pyridin-4-yl)-1H-pyrazol-1-yl]phenyl}benzamide (1350473-82-3)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 18 h / 20 °C

1.2: 20 °C

2.1: copper(l) iodide; potassium carbonate; L-proline / dimethyl sulfoxide / 8 h / 90 °C / Inert atmosphere

3.1: palladium on activated charcoal; hydrogen / tetrahydrofuran / 2 h / 20 °C

4.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 0 - 80 °C / Inert atmosphere

With copper(l) iodide; palladium on activated charcoal; hydrogen; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; L-proline; In tetrahydrofuran; dimethyl sulfoxide; N,N-dimethyl-formamide;

DOI:10.1016/j.ejmech.2011.08.013

Reference yield:

methyl 4-chloro-3-methoxybenzoate (116022-18-5) → 3,5-dichloro-N-{4-[3-(4-chloro-3-methoxyphenyl)-4-(pyridin-4-yl)-1H-pyrazol-1-yl]phenyl}benzamide (1350473-82-3)

Guidance literature:

Multi-step reaction with 5 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / -25 - 20 °C

2.1: 18 h / 20 °C

2.2: 20 °C

3.1: copper(l) iodide; potassium carbonate; L-proline / dimethyl sulfoxide / 8 h / 90 °C / Inert atmosphere

4.1: palladium on activated charcoal; hydrogen / tetrahydrofuran / 2 h / 20 °C

5.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 0 - 80 °C / Inert atmosphere

With copper(l) iodide; palladium on activated charcoal; hydrogen; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; L-proline; lithium hexamethyldisilazane; In tetrahydrofuran; dimethyl sulfoxide; N,N-dimethyl-formamide;

DOI:10.1016/j.ejmech.2011.08.013

upstream raw materials:

methyl 4-chloro-3-methoxybenzoate

1-(4-chloro-3-methoxyphenyl)-2-(pyridin-4-yl)ethanone

4-(3-(4-chloro-3-methoxyphenyl)-1H-pyrazol-4-yl)pyridine

4-[3-(4-chloro-3-methoxyphenyl)-1-(4-nitrophenyl)-1H-pyrazol-4-yl]pyridine

Downstream raw materials:

3,5-dichloro-N-{4-[3-(4-chloro-3-hydroxyphenyl)-4-(pyridin-4-yl)-1H-pyrazol-1-yl]phenyl}benzamide

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1350473-82-3 3,5-dichloro-N-{4-[3-(4-chloro-3-methoxyphenyl)-4-(pyridin-4-yl)-1H-pyrazol-1-yl]phenyl}benzamide

Send

Send

Metric Ton KG G Pound L ML

Send

Send