(S)-3-(5-chloro-2-methoxyphenyl)-3-fluoro-2-oxo-6-(trifluoromethyl)-indoline 1-carbonyl chloride

Base Information

• Chemical Name: (S)-3-(5-chloro-2-methoxyphenyl)-3-fluoro-2-oxo-6-(trifluoromethyl)-indoline 1-carbonyl chloride
• CAS No.: 607740-52-3
• Molecular Formula: C₁₇H₉Cl₂F₄NO₃
• Molecular Weight: 422.163
• Mol file: 607740-52-3.mol

Synonyms:(S)-3-(5-chloro-2-methoxyphenyl)-3-fluoro-2-oxo-6-(trifluoromethyl)-indoline 1-carbonyl chloride

Chemical Property of (S)-3-(5-chloro-2-methoxyphenyl)-3-fluoro-2-oxo-6-(trifluoromethyl)-indoline 1-carbonyl chloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-3-(5-chloro-2-methoxyphenyl)-3-fluoro-2-oxo-6-(trifluoromethyl)-indoline 1-carbonyl chloride

There total 1 articles about (S)-3-(5-chloro-2-methoxyphenyl)-3-fluoro-2-oxo-6-(trifluoromethyl)-indoline 1-carbonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

phosgene (75-44-5) + (S)-(+)-3-(5-chloro-2-methoxyphenyl)-3-fluoro-1,3-dihydro-6-(trifluoromethyl)-2H-indol-2-one (187523-35-9,187523-36-0) → (S)-3-(5-chloro-2-methoxyphenyl)-3-fluoro-2-oxo-6-(trifluoromethyl)-indoline 1-carbonyl chloride (607740-52-3)

Guidance literature:

With pyridine; In dichloromethane; toluene; at 20 ℃;

Reference yield: 52.0%

(S)-2-hydroxy-propionic acid benzyloxycarbonylmethyl ester (864775-21-3) + (S)-3-(5-chloro-2-methoxyphenyl)-3-fluoro-2-oxo-6-(trifluoromethyl)-indoline 1-carbonyl chloride (607740-52-3) → (S)-((S)-1-(2-(benzyloxy)-2-oxoethoxy)-1-oxopropan-2-yl) 3-(5-chloro-2-methoxyphenyl)-3-fluoro-2-oxo-6-(trifluoromethyl)indoline-1-carboxylate (864775-22-4)

Guidance literature:

In dichloromethane; toluene; at 20 ℃; for 24h;

Reference yield:

(S)-3-(5-chloro-2-methoxyphenyl)-3-fluoro-2-oxo-6-(trifluoromethyl)-indoline 1-carbonyl chloride (607740-52-3) + benzyl glycolate (30379-58-9) → (S)-2-(3-(5-chloro-2-methoxyphenyl)-3-fluoro-2-oxo-6-(trifluoromethyl)indoline-1-carbonyloxy)acetic acid, benzyloxycarbonylmethyl ester (864775-23-5)

Guidance literature:

With pyridine; In dichloromethane; toluene; at 20 ℃; for 1h;

upstream raw materials:

phosgene

(S)-(+)-3-(5-chloro-2-methoxyphenyl)-3-fluoro-1,3-dihydro-6-(trifluoromethyl)-2H-indol-2-one

Downstream raw materials:

(S)-3-(5-Chloro-2-methoxy-phenyl)-3-fluoro-2-oxo-6-trifluoromethyl-2,3-dihydro-indole-1-carboxylic acid 3-benzyloxycarbonyl-propyl ester

(S)-2-(3-(5-chloro-2-methoxyphenyl)-3-fluoro-2-oxo-6-(trifluoromethyl)indoline-1-carbonyloxy)acetic acid, benzyloxycarbonylmethyl ester

(S)-((S)-1-(2-(benzyloxy)-2-oxoethoxy)-1-oxopropan-2-yl) 3-(5-chloro-2-methoxyphenyl)-3-fluoro-2-oxo-6-(trifluoromethyl)indoline-1-carboxylate