(2S)-2-(tert-butoxy)-2-(7-(8-fluoro-5-methylchroman-6-yl)-5-methyl-2-(2'-methyl-[1,1'-biphenyl]-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)acetic acid

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Chemical Name:(2S)-2-(tert-butoxy)-2-(7-(8-fluoro-5-methylchroman-6-yl)-5-methyl-2-(2'-methyl-[1,1'-biphenyl]-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)acetic acid
CAS No.:1364592-89-1
Molecular Formula:C₃₆H₃₆FN₃O₄
Molecular Weight:593.698
Hs Code.:

Synonyms:(2S)-2-(tert-butoxy)-2-(7-(8-fluoro-5-methylchroman-6-yl)-5-methyl-2-(2'-methyl-[1,1'-biphenyl]-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)acetic acid

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Chemical Property of (2S)-2-(tert-butoxy)-2-(7-(8-fluoro-5-methylchroman-6-yl)-5-methyl-2-(2'-methyl-[1,1'-biphenyl]-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)acetic acid

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Technology Process of (2S)-2-(tert-butoxy)-2-(7-(8-fluoro-5-methylchroman-6-yl)-5-methyl-2-(2'-methyl-[1,1'-biphenyl]-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)acetic acid

There total 14 articles about (2S)-2-(tert-butoxy)-2-(7-(8-fluoro-5-methylchroman-6-yl)-5-methyl-2-(2'-methyl-[1,1'-biphenyl]-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 1364597-70-5
(2S)-methyl 2-(tert-butoxy)-2-(7-(8-fluoro-5-methylchroman-6-yl)-5-methyl-2-(2'-methyl-[1,1'-biphenyl]-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)acetate

: 1364592-89-1
(2S)-2-(tert-butoxy)-2-(7-(8-fluoro-5-methylchroman-6-yl)-5-methyl-2-(2'-methyl-[1,1'-biphenyl]-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)acetic acid

Guidance literature:: (2S)-methyl 2-(tert-butoxy)-2-(7-(8-fluoro-5-methylchroman-6-yl)-5-methyl-2-(2'-methyl-[1,1'-biphenyl]-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)acetate; With water; sodium hydroxide; In 1,4-dioxane; at 50 ℃; for 2h;

With acetic acid; In 1,4-dioxane; water;

Reference yield:

: 10420-33-4
dimethyl 2-acetylsuccinate

: 1364592-89-1
(2S)-2-(tert-butoxy)-2-(7-(8-fluoro-5-methylchroman-6-yl)-5-methyl-2-(2'-methyl-[1,1'-biphenyl]-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)acetic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: toluene-4-sulfonic acid / o-xylene / 2 h / Reflux

2.1: trichlorophosphate / 2.5 h / Reflux

3.1: potassium hexamethylsilazane / tetrahydrofuran / 1 h / -78 °C

3.2: 2.5 h / -78 °C

4.1: perchloric acid / dichloromethane / 5 h / 20 °C

5.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 0.75 h / 115 °C / Microwave irradiation

6.1: Chiralpak AD-H / carbon dioxide; methanol / 35 °C / 112511 Torr / Resolution of racemate

7.1: potassium phosphate / palladium diacetate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / N,N-dimethyl-formamide / 0.5 h / 130 °C / Microwave irradiation

8.1: sodium hydroxide; water / 1,4-dioxane / 2 h / 50 °C

With potassium phosphate; perchloric acid; water; potassium hexamethylsilazane; potassium carbonate; sodium hydroxide; trichlorophosphate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium diacetate; toluene-4-sulfonic acid; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; o-xylene; carbon dioxide; N,N-dimethyl-formamide;

Reference yield:

: 1364597-43-2
methyl 2-(2-(3-chlorophenyl)-7-hydroxy-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)acetate

: 1364592-89-1
(2S)-2-(tert-butoxy)-2-(7-(8-fluoro-5-methylchroman-6-yl)-5-methyl-2-(2'-methyl-[1,1'-biphenyl]-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)acetic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: trichlorophosphate / 2.5 h / Reflux

2.1: potassium hexamethylsilazane / tetrahydrofuran / 1 h / -78 °C

2.2: 2.5 h / -78 °C

3.1: perchloric acid / dichloromethane / 5 h / 20 °C

4.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 0.75 h / 115 °C / Microwave irradiation

5.1: Chiralpak AD-H / carbon dioxide; methanol / 35 °C / 112511 Torr / Resolution of racemate

6.1: potassium phosphate / palladium diacetate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / N,N-dimethyl-formamide / 0.5 h / 130 °C / Microwave irradiation

7.1: sodium hydroxide; water / 1,4-dioxane / 2 h / 50 °C

With potassium phosphate; perchloric acid; water; potassium hexamethylsilazane; potassium carbonate; sodium hydroxide; trichlorophosphate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium diacetate; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; carbon dioxide; N,N-dimethyl-formamide;