(2S)-methyl 2-(tert-butoxy)-2-(7-(8-fluoro-5-methylchroman-6-yl)-5-methyl-2-(2'-methyl-[1,1'-biphenyl]-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)acetate

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Chemical Name:(2S)-methyl 2-(tert-butoxy)-2-(7-(8-fluoro-5-methylchroman-6-yl)-5-methyl-2-(2'-methyl-[1,1'-biphenyl]-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)acetate
CAS No.:1364597-70-5
Molecular Formula:C₃₇H₃₈FN₃O₄
Molecular Weight:607.725
Hs Code.:

Synonyms:(2S)-methyl 2-(tert-butoxy)-2-(7-(8-fluoro-5-methylchroman-6-yl)-5-methyl-2-(2'-methyl-[1,1'-biphenyl]-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)acetate

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Chemical Property of (2S)-methyl 2-(tert-butoxy)-2-(7-(8-fluoro-5-methylchroman-6-yl)-5-methyl-2-(2'-methyl-[1,1'-biphenyl]-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)acetate

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Technology Process of (2S)-methyl 2-(tert-butoxy)-2-(7-(8-fluoro-5-methylchroman-6-yl)-5-methyl-2-(2'-methyl-[1,1'-biphenyl]-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)acetate

There total 12 articles about (2S)-methyl 2-(tert-butoxy)-2-(7-(8-fluoro-5-methylchroman-6-yl)-5-methyl-2-(2'-methyl-[1,1'-biphenyl]-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.2%

: 1364597-66-9
(2S)-methyl 2-(tert-butoxy)-2-(2-(3-chlorophenyl)-7-(8-fluoro-5-methylchroman-6-yl)-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)acetate

: 16419-60-6
2-Methylphenylboronic acid

: 1364597-70-5
(2S)-methyl 2-(tert-butoxy)-2-(7-(8-fluoro-5-methylchroman-6-yl)-5-methyl-2-(2'-methyl-[1,1'-biphenyl]-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)acetate

Guidance literature:: With potassium phosphate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; In N,N-dimethyl-formamide; at 130 ℃; for 0.5h; Microwave irradiation;

Reference yield:

: 10420-33-4
dimethyl 2-acetylsuccinate

: 1364597-70-5
(2S)-methyl 2-(tert-butoxy)-2-(7-(8-fluoro-5-methylchroman-6-yl)-5-methyl-2-(2'-methyl-[1,1'-biphenyl]-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)acetate

Guidance literature:: Multi-step reaction with 7 steps

1.1: toluene-4-sulfonic acid / o-xylene / 2 h / Reflux

2.1: trichlorophosphate / 2.5 h / Reflux

3.1: potassium hexamethylsilazane / tetrahydrofuran / 1 h / -78 °C

3.2: 2.5 h / -78 °C

4.1: perchloric acid / dichloromethane / 5 h / 20 °C

5.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 0.75 h / 115 °C / Microwave irradiation

6.1: Chiralpak AD-H / carbon dioxide; methanol / 35 °C / 112511 Torr / Resolution of racemate

7.1: potassium phosphate / palladium diacetate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / N,N-dimethyl-formamide / 0.5 h / 130 °C / Microwave irradiation

With potassium phosphate; perchloric acid; potassium hexamethylsilazane; potassium carbonate; trichlorophosphate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium diacetate; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; dichloromethane; o-xylene; carbon dioxide; N,N-dimethyl-formamide;

Reference yield:

: 1364597-43-2
methyl 2-(2-(3-chlorophenyl)-7-hydroxy-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)acetate

: 1364597-70-5
(2S)-methyl 2-(tert-butoxy)-2-(7-(8-fluoro-5-methylchroman-6-yl)-5-methyl-2-(2'-methyl-[1,1'-biphenyl]-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)acetate

Guidance literature:: Multi-step reaction with 6 steps

1.1: trichlorophosphate / 2.5 h / Reflux

2.1: potassium hexamethylsilazane / tetrahydrofuran / 1 h / -78 °C

2.2: 2.5 h / -78 °C

3.1: perchloric acid / dichloromethane / 5 h / 20 °C

4.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 0.75 h / 115 °C / Microwave irradiation

5.1: Chiralpak AD-H / carbon dioxide; methanol / 35 °C / 112511 Torr / Resolution of racemate

6.1: potassium phosphate / palladium diacetate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / N,N-dimethyl-formamide / 0.5 h / 130 °C / Microwave irradiation

With potassium phosphate; perchloric acid; potassium hexamethylsilazane; potassium carbonate; trichlorophosphate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium diacetate; In tetrahydrofuran; methanol; dichloromethane; carbon dioxide; N,N-dimethyl-formamide;