2,3,5-tri-O-benzyl-4-O-methanesulfonyl-1-O-trityl-L-lyxitol

Base Information

• Chemical Name: 2,3,5-tri-O-benzyl-4-O-methanesulfonyl-1-O-trityl-L-lyxitol
• CAS No.: 1437657-96-9
• Molecular Formula: C₄₆H₄₆O₇S
• Molecular Weight: 742.933
• Mol file: 1437657-96-9.mol

Synonyms:2,3,5-tri-O-benzyl-4-O-methanesulfonyl-1-O-trityl-L-lyxitol

Chemical Property of 2,3,5-tri-O-benzyl-4-O-methanesulfonyl-1-O-trityl-L-lyxitol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,3,5-tri-O-benzyl-4-O-methanesulfonyl-1-O-trityl-L-lyxitol

There total 6 articles about 2,3,5-tri-O-benzyl-4-O-methanesulfonyl-1-O-trityl-L-lyxitol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

2,3,5-tri-O-benzyl-1-O-trityl-L-lyxitol (1437657-93-6) + methanesulfonyl chloride (124-63-0) → 2,3,5-tri-O-benzyl-4-O-methanesulfonyl-1-O-trityl-L-lyxitol (1437657-96-9)

Guidance literature:

With pyridine; at 0 - 4 ℃;

DOI:10.1021/ol4012053

Reference yield:

benzyl bromide (100-39-0) → 2,3,5-tri-O-benzyl-4-O-methanesulfonyl-1-O-trityl-L-lyxitol (1437657-96-9)

Guidance literature:

Multi-step reaction with 5 steps

1.1: acetyl chloride

1.2: 2 h / 20 °C

2.1: sulfuric acid / acetic acid / 1 h / 100 °C

3.1: sodium tetrahydroborate / ethanol / 5 h / 0 - 20 °C

4.1: triethylamine; dmap / dichloromethane / 144 h

5.1: pyridine / 0 - 4 °C

With pyridine; dmap; sodium tetrahydroborate; sulfuric acid; triethylamine; acetyl chloride; In ethanol; dichloromethane; acetic acid;

DOI:10.1021/ol4012053

Reference yield:

L-arabinofuranose (87-72-9,608-45-7,608-46-8,608-47-9,2460-44-8,6748-95-4,6763-34-4,7261-26-9,7283-06-9,7283-07-0,7296-55-1,7296-56-2,7296-58-4,7296-59-5,7296-60-8,7296-61-9,7296-62-0,7322-30-7,10257-31-5,10257-32-6,10257-33-7,10257-34-8,10257-35-9,19982-83-3,20242-88-0,28697-53-2,41546-41-2,89299-64-9,107655-34-5,115794-06-4,115794-07-5,130550-15-1,130606-21-2,36562-42-2) → 2,3,5-tri-O-benzyl-4-O-methanesulfonyl-1-O-trityl-L-lyxitol (1437657-96-9)

Guidance literature:

Multi-step reaction with 5 steps

1.1: acetyl chloride

1.2: 2 h / 20 °C

2.1: sulfuric acid / acetic acid / 1 h / 100 °C

3.1: sodium tetrahydroborate / ethanol / 5 h / 0 - 20 °C

4.1: triethylamine; dmap / dichloromethane / 144 h

5.1: pyridine / 0 - 4 °C

With pyridine; dmap; sodium tetrahydroborate; sulfuric acid; triethylamine; acetyl chloride; In ethanol; dichloromethane; acetic acid;

DOI:10.1021/ol4012053

upstream raw materials:

benzyl bromide

2,3,5-tri-O-benzyl-1-O-trityl-L-lyxitol

methanesulfonyl chloride

L-arabinofuranose

Downstream raw materials:

2,3,5-tri-O-benzyl-4-deoxy-4-azido-1-O-trityl-D-ribitol

2,3,5-tri-O-benzyl-4-deoxy-4-azido-D-ribitol

2,3,5-tri-O-benzyl-4-deoxy-4-azido-D-ribose

C₂₆H₂₇NO₃