(2-Bromophenyl)(4-methoxyphenyl)methanol

Base Information

• Chemical Name: (2-Bromophenyl)(4-methoxyphenyl)methanol
• CAS No.: 59142-64-2
• Molecular Formula: C₁₄H₁₃BrO₂
• Molecular Weight: 293.16
• DSSTox Substance ID: DTXSID101265054
• Nikkaji Number: J2.615.878H
• Mol file: 59142-64-2.mol

Synonyms:(2-Bromophenyl)(4-methoxyphenyl)methanol;2-bromo-4'-methoxybenzhydrol;59142-64-2;SCHEMBL5671557;WSGPNOCUUSZBHY-UHFFFAOYSA-N;DTXSID101265054;AKOS010334960;(2-bromophenyl)-(4-methoxyphenyl)methanol;2-bromo-alpha-(4-methoxyphenyl)benzyl alcohol;2-Bromo-alpha-(4-methoxyphenyl)benzenemethanol

Chemical Property of (2-Bromophenyl)(4-methoxyphenyl)methanol

Chemical Property:

• XLogP3: 3.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 292.00989
• Heavy Atom Count: 17
• Complexity: 226

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)C(C2=CC=CC=C2Br)O

Technology Process of (2-Bromophenyl)(4-methoxyphenyl)methanol

There total 6 articles about (2-Bromophenyl)(4-methoxyphenyl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

1-bromo-4-methoxy-benzene (104-92-7) + ortho-bromobenzaldehyde (6630-33-7) → 2-bromo-α-(4-methoxyphenyl)benzyl alcohol (59142-64-2)

Guidance literature:

1-bromo-4-methoxy-benzene; With n-butyllithium;

ortho-bromobenzaldehyde; In tetrahydrofuran; at 0 - 20 ℃; for 1.5h; Inert atmosphere;

DOI:10.1016/j.tetlet.2016.06.123

Reference yield: 86.0%

4-methoxyphenylboronic acid (5720-07-0) + ortho-bromobenzaldehyde (6630-33-7) → 2-bromo-α-(4-methoxyphenyl)benzyl alcohol (59142-64-2)

Guidance literature:

With potassium phosphate; platinacycle; In toluene; at 60 - 80 ℃;

DOI:10.1021/ol800774c

Reference yield: 76.0%

4-methoxyphenyl magnesium bromide (13139-86-1) + ortho-bromobenzaldehyde (6630-33-7) → 2-bromo-α-(4-methoxyphenyl)benzyl alcohol (59142-64-2)

Guidance literature:

In tetrahydrofuran; at -30 ℃; for 1h; Inert atmosphere;

DOI:10.1002/anie.201209983

upstream raw materials:

2-bromo-4'-methoxy-benzophenone

1-bromo-4-methoxy-benzene

ortho-bromobenzaldehyde

4-methoxyphenylboronic acid

Downstream raw materials:

2-bromo-4'-methoxybenzophenone 4-methyl-phenylsulfonylhydrazone