2-Bromo-4'-methoxybenzophenone

Base Information

• Chemical Name: 2-Bromo-4'-methoxybenzophenone
• CAS No.: 59142-63-1
• Molecular Formula: C14H11BrO2
• Molecular Weight: 291.144
• Hs Code.: 2914700090
• DSSTox Substance ID: DTXSID20428500
• Nikkaji Number: J1.106.894D
• Mol file: 59142-63-1.mol

Synonyms:2-BROMO-4'-METHOXYBENZOPHENONE;59142-63-1;(2-bromophenyl)-(4-methoxyphenyl)methanone;(2-bromophenyl)(4-methoxyphenyl)methanone;MFCD00626439;SCHEMBL11575471;DTXSID20428500;KAQIWWJREILQAQ-UHFFFAOYSA-N;STK006266;AKOS000277353;(2-Bromophenyl)(4-methoxy-phenyl)methanone;2-bromo-4'-methoxybenzophenone, AldrichCPR;CS-0357137;J-500668

Chemical Property of 2-Bromo-4'-methoxybenzophenone

Chemical Property:

• Vapor Pressure: 2.33E-06mmHg at 25°C
• Melting Point: 90–92°C
• Boiling Point: 392.2°C at 760 mmHg
• Flash Point: 191°C
• PSA: 26.30000
• Density: 1.401g/cm³
• LogP: 3.68870
• XLogP3: 3.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 289.99424
• Heavy Atom Count: 17
• Complexity: 259

Purity/Quality:

97% ^*data from raw suppliers

2-Bromo-4'-methoxybenzophenone 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)C(=O)C2=CC=CC=C2Br

Technology Process of 2-Bromo-4'-methoxybenzophenone

There total 19 articles about 2-Bromo-4'-methoxybenzophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

methoxybenzene (100-66-3) + 2-bromobenzoic acid chloride (7154-66-7) → 2-bromo-4'-methoxy-benzophenone (59142-63-1)

Guidance literature:

With aluminium trichloride; In chloroform; at 20 ℃; for 12h;

DOI:10.3390/70100018

Reference yield: 80.0%

p-methylanizole (104-93-8) + 2-bromobenzoic acid chloride (7154-66-7) → 2-bromo-4'-methoxy-benzophenone (59142-63-1)

Guidance literature:

p-methylanizole; 2-bromobenzoic acid chloride; In dichloromethane; at 0 ℃; for 0.5h; Inert atmosphere; Glovebox;

With aluminum (III) chloride; In dichloromethane; at 0 - 20 ℃; Inert atmosphere; Glovebox;

DOI:10.1021/acs.orglett.9b01056

Reference yield: 72.0%

methoxybenzene (100-66-3) + 2-bromobenzoic-acid (88-65-3) → p-methylanizole (104-93-8) + 2-methylmethoxybenzene (578-58-5) + 2-bromobenzoic acid phenyl ester (1989-22-6) + 2-bromo-4'-methoxy-benzophenone (59142-63-1)

Guidance literature:

With erbium(III) triflate; In neat (no solvent); at 220 ℃; for 0.5h; Microwave irradiation;

DOI:10.1016/j.tetlet.2014.12.038

upstream raw materials:

methoxybenzene

2-bromobenzoic-acid

4-methoxy-benzoyl chloride

(2-bromophenyl)zinc(II)iodide

Downstream raw materials:

2,2'-bis(4-methoxybenzoyl)biphenyl

1-bromo-2-(4-methoxybenzyl)benzene

2-bromo-α-(4-methoxyphenyl)benzyl alcohol

2-bromo-4'-methoxybenzophenone 4-methyl-phenylsulfonylhydrazone