7-methoxy-5-(p-tolyl)-3-(trifluoromethyl)-10,11-dihydro-5H-benzo[b]pyrido[2,3-f]azepine

Base Information

Chemical Name:7-methoxy-5-(p-tolyl)-3-(trifluoromethyl)-10,11-dihydro-5H-benzo[b]pyrido[2,3-f]azepine
CAS No.:1512811-96-9
Molecular Formula:C₂₂H₁₉F₃N₂O
Molecular Weight:384.401
Hs Code.:

Synonyms:7-methoxy-5-(p-tolyl)-3-(trifluoromethyl)-10,11-dihydro-5H-benzo[b]pyrido[2,3-f]azepine

Suppliers and Price of 7-methoxy-5-(p-tolyl)-3-(trifluoromethyl)-10,11-dihydro-5H-benzo[b]pyrido[2,3-f]azepine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 7-methoxy-5-(p-tolyl)-3-(trifluoromethyl)-10,11-dihydro-5H-benzo[b]pyrido[2,3-f]azepine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 7-methoxy-5-(p-tolyl)-3-(trifluoromethyl)-10,11-dihydro-5H-benzo[b]pyrido[2,3-f]azepine

There total 3 articles about 7-methoxy-5-(p-tolyl)-3-(trifluoromethyl)-10,11-dihydro-5H-benzo[b]pyrido[2,3-f]azepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 3-chloro-5-(trifluoromethyl)-2-vinylpyridine

: 106-49-0,12221-03-3
p-toluidine

: 219735-99-6
2-chloro-4-methoxyphenylboronic acid

: 1512811-96-9
7-methoxy-5-(p-tolyl)-3-(trifluoromethyl)-10,11-dihydro-5H-benzo[b]pyrido[2,3-f]azepine

Guidance literature:: With [Rh(OH)(cod)]2; chloro(2-dicyclohexylphosphino-2′,6′-diisopropoxy-1,1′-biphenyl)[2-(2-aminoethyl)phenyl]palladium(II); potassium carbonate; XPhos; In 1,4-dioxane; water; for 22h; Inert atmosphere; Heating;
DOI:10.1021/ol4030925

Reference yield:

: 75806-84-7
2-bromo-3-chloro-5-(trifluoromethyl)pyridine

: 1512811-96-9
7-methoxy-5-(p-tolyl)-3-(trifluoromethyl)-10,11-dihydro-5H-benzo[b]pyrido[2,3-f]azepine

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / tetrahydrofuran / 24 h / 80 °C / Inert atmosphere

2: potassium carbonate; [Rh(OH)(cod)]2; chloro(2-dicyclohexylphosphino-2′,6′-diisopropoxy-1,1′-biphenyl)[2-(2-aminoethyl)phenyl]palladium(II); XPhos / water; 1,4-dioxane / 22 h / Inert atmosphere; Heating

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; [Rh(OH)(cod)]2; chloro(2-dicyclohexylphosphino-2′,6′-diisopropoxy-1,1′-biphenyl)[2-(2-aminoethyl)phenyl]palladium(II); potassium carbonate; caesium carbonate; XPhos; In tetrahydrofuran; 1,4-dioxane; water;
DOI:10.1021/ol4030925

Reference yield:

: 69045-84-7
2,3-dichloro-5-trifluoromethylpyridine

: 1512811-96-9
7-methoxy-5-(p-tolyl)-3-(trifluoromethyl)-10,11-dihydro-5H-benzo[b]pyrido[2,3-f]azepine

Guidance literature:: Multi-step reaction with 3 steps

1: trimethylsilyl bromide / 15 h / 100 °C / Inert atmosphere

2: caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / tetrahydrofuran / 24 h / 80 °C / Inert atmosphere

3: potassium carbonate; [Rh(OH)(cod)]2; chloro(2-dicyclohexylphosphino-2′,6′-diisopropoxy-1,1′-biphenyl)[2-(2-aminoethyl)phenyl]palladium(II); XPhos / water; 1,4-dioxane / 22 h / Inert atmosphere; Heating

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; [Rh(OH)(cod)]2; trimethylsilyl bromide; chloro(2-dicyclohexylphosphino-2′,6′-diisopropoxy-1,1′-biphenyl)[2-(2-aminoethyl)phenyl]palladium(II); potassium carbonate; caesium carbonate; XPhos; In tetrahydrofuran; 1,4-dioxane; water;
DOI:10.1021/ol4030925