methyl (5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)ethanoate

Base Information

• Chemical Name: methyl (5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)ethanoate
• CAS No.: 134456-94-3
• Molecular Formula: C₈H₁₀N₂O₄
• Molecular Weight: 198.178
• Mol file: 134456-94-3.mol

Synonyms:methyl (5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)ethanoate

Chemical Property of methyl (5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)ethanoate

Chemical Property:

Purity/Quality:

99%, ^*data from raw suppliers

Methyl 2-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)acetate 97% ^*data from reagent suppliers

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Technology Process of methyl (5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)ethanoate

There total 2 articles about methyl (5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)ethanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

methanol (67-56-1) + thymidyl acetic acid (20924-05-4) → methyl (5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)ethanoate (134456-94-3)

Guidance literature:

With sulfuric acid; for 1h; Heating;

DOI:10.1016/j.tet.2007.03.033

Reference yield:

bromoacetic acid methyl ester (96-32-2) + thymin (65-71-4,28806-14-6,691841-57-3) → methyl (5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)ethanoate (134456-94-3)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; for 24h;

DOI:10.1021/ja00031a062

Reference yield: 76.0%

Benzyloxymethyl chloride (3587-60-8) + methyl (5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)ethanoate (134456-94-3) → 3-Benzyloxymethyl-1-(methoxycarbonylmethyl)thymine (368889-99-0)

Guidance literature:

methyl (5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)ethanoate; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 0.333333h;

Benzyloxymethyl chloride; In N,N-dimethyl-formamide; at 20 ℃; for 2.5h; Further stages.;

DOI:10.1039/b101759o

upstream raw materials:

bromoacetic acid methyl ester

thymin

methanol

thymidyl acetic acid

Downstream raw materials:

3-Benzyloxymethyl-1-(methoxycarbonylmethyl)thymine

{{2-[1-(4,4-dimethyl-2,6-dioxo-cyclohexylidene)-ethylamino]-ethyl}-[(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-acetic acid methyl ester

N-[2-(thymin-1-yl)-acetyl]-N-{2-[1-(4,4-dimethyl-2,6-dioxo-cyclohexyliden)-ethylamino]-ethyl}glycine

3-Benzyloxymethyl-1-[4-hydroxy-4-(hydroxymethyl)-2-oxotetrahydrofuran-3-yl]thymine

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