C-(7,7-dimethyl-2-oxo-bicyclo[2.2.1]hept-1-yl)-N-{4-[3-(4-methoxy-phenyl)-acryloyl]-phenyl}-methanesulfonamide

Base Information

• Chemical Name: C-(7,7-dimethyl-2-oxo-bicyclo[2.2.1]hept-1-yl)-N-{4-[3-(4-methoxy-phenyl)-acryloyl]-phenyl}-methanesulfonamide
• CAS No.: 628291-43-0
• Molecular Formula: C₂₆H₂₉NO₅S
• Molecular Weight: 467.586

Synonyms:C-(7,7-dimethyl-2-oxo-bicyclo[2.2.1]hept-1-yl)-N-{4-[3-(4-methoxy-phenyl)-acryloyl]-phenyl}-methanesulfonamide

Chemical Property of C-(7,7-dimethyl-2-oxo-bicyclo[2.2.1]hept-1-yl)-N-{4-[3-(4-methoxy-phenyl)-acryloyl]-phenyl}-methanesulfonamide

Chemical Property:

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Technology Process of C-(7,7-dimethyl-2-oxo-bicyclo[2.2.1]hept-1-yl)-N-{4-[3-(4-methoxy-phenyl)-acryloyl]-phenyl}-methanesulfonamide

There total 3 articles about C-(7,7-dimethyl-2-oxo-bicyclo[2.2.1]hept-1-yl)-N-{4-[3-(4-methoxy-phenyl)-acryloyl]-phenyl}-methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4-[(+)-camphor-10'-sulfonylamino]acetophenone (628291-40-7) + 4-methoxy-benzaldehyde (123-11-5) → C-(7,7-dimethyl-2-oxo-bicyclo[2.2.1]hept-1-yl)-N-{4-[3-(4-methoxy-phenyl)-acryloyl]-phenyl}-methanesulfonamide (628291-43-0)

Guidance literature:

With potassium hydroxide; In ethanol; for 0.166667h; Heating;

DOI:10.1080/10426500307861

Reference yield:

Camphorsulfonyl chloride (21286-54-4) → C-(7,7-dimethyl-2-oxo-bicyclo[2.2.1]hept-1-yl)-N-{4-[3-(4-methoxy-phenyl)-acryloyl]-phenyl}-methanesulfonamide (628291-43-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 96 percent / (C₂H₅)3N / tetrahydrofuran / 3 h / 20 °C

2: 95 percent / aq. KOH / ethanol / 0.17 h / Heating

With potassium hydroxide; triethylamine; In tetrahydrofuran; ethanol;

DOI:10.1080/10426500307861

Reference yield:

p-aminobenzophenone (99-92-3) → C-(7,7-dimethyl-2-oxo-bicyclo[2.2.1]hept-1-yl)-N-{4-[3-(4-methoxy-phenyl)-acryloyl]-phenyl}-methanesulfonamide (628291-43-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 96 percent / (C₂H₅)3N / tetrahydrofuran / 3 h / 20 °C

2: 95 percent / aq. KOH / ethanol / 0.17 h / Heating

With potassium hydroxide; triethylamine; In tetrahydrofuran; ethanol;

DOI:10.1080/10426500307861

upstream raw materials:

4-[(+)-camphor-10'-sulfonylamino]acetophenone

4-methoxy-benzaldehyde

Camphorsulfonyl chloride

p-aminobenzophenone

Downstream raw materials:

N-{4-[5-cyano-4-(4-methoxy-phenyl)-6-thioxo-1,6-dihydro-pyridin-2-yl]-phenyl}-C-(7,7-dimethyl-2-oxo-bicyclo[2.2.1]hept-1-yl)-methanesulfonamide

N-{4-[5-cyano-4-(4-methoxy-phenyl)-6-oxo-1,6-dihydro-pyridin-2-yl]-phenyl}-C-(7,7-dimethyl-2-oxo-bicyclo[2.2.1]hept-1-yl)-methanesulfonamide

N-{4-[1-acetyl-5-cyano-4-(4-methoxy-phenyl)-6-oxo-1,6-dihydro-pyridin-2-yl]-phenyl}-C-(7,7-dimethyl-2-oxo-bicyclo[2.2.1]hept-1-yl)-methanesulfonamide

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