Technology Process of 1-(2,2-diethoxyethoxy)-4-fluoro-2-methoxybenzene
There total 3 articles about 1-(2,2-diethoxyethoxy)-4-fluoro-2-methoxybenzene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
2-methoxy-4-fluorophenol;
With
sodium hydride;
In
N,N-dimethyl-formamide;
at 0 ℃;
Bromoacetaldehyde diethyl acetal;
In
N,N-dimethyl-formamide;
at 160 - 170 ℃;
DOI:10.1021/jm0304010
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 100 percent / K2CO3 / dimethylsulfoxide / 2 h / 20 °C
2.1: 3-tert-butyl-4-hydroxy-5-methylphenyl sulfide; m-CPBA / CH2Cl2 / Heating
2.2: 71 percent / aq. NaOH / ethanol / 2 h
3.1: NaH / dimethylformamide / 0 °C
3.2: 51 percent / dimethylformamide / 160 - 170 °C
With
6,6'-di-tert-butyl-4,4'-thiodi-o-cresol; sodium hydride; potassium carbonate; 3-chloro-benzenecarboperoxoic acid;
In
dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
2.1: Bayer-Villiger reaction;
DOI:10.1021/jm0304010
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 3-tert-butyl-4-hydroxy-5-methylphenyl sulfide; m-CPBA / CH2Cl2 / Heating
1.2: 71 percent / aq. NaOH / ethanol / 2 h
2.1: NaH / dimethylformamide / 0 °C
2.2: 51 percent / dimethylformamide / 160 - 170 °C
With
6,6'-di-tert-butyl-4,4'-thiodi-o-cresol; sodium hydride; 3-chloro-benzenecarboperoxoic acid;
In
dichloromethane; N,N-dimethyl-formamide;
1.1: Bayer-Villiger reaction;
DOI:10.1021/jm0304010
