(6-methyl-2-(4-nitrophenylsulfonamido)pyrimidin-4-yl)trimethylammonium chloride

Base Information

• Chemical Name: (6-methyl-2-(4-nitrophenylsulfonamido)pyrimidin-4-yl)trimethylammonium chloride
• CAS No.: 1421943-67-0
• Molecular Formula: C₁₄H₁₈N₅O₄S*Cl
• Molecular Weight: 387.847
• Mol file: 1421943-67-0.mol

Synonyms:(6-methyl-2-(4-nitrophenylsulfonamido)pyrimidin-4-yl)trimethylammonium chloride

Chemical Property of (6-methyl-2-(4-nitrophenylsulfonamido)pyrimidin-4-yl)trimethylammonium chloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (6-methyl-2-(4-nitrophenylsulfonamido)pyrimidin-4-yl)trimethylammonium chloride

There total 4 articles about (6-methyl-2-(4-nitrophenylsulfonamido)pyrimidin-4-yl)trimethylammonium chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

N-(4-chloro-6-methylpyrimidin-2-yl)-4-nitrobenzenesulfonamide (860515-73-7) + trimethylamine (75-50-3) → (6-methyl-2-(4-nitrophenylsulfonamido)pyrimidin-4-yl)trimethylammonium chloride (1421943-67-0)

Guidance literature:

In tetrahydrofuran; ethanol; at 0 ℃; for 0.166667h; Sealed tube; Inert atmosphere;

DOI:10.3998/ark.5550190.0013.914

Reference yield:

4-Nitrobenzenesulfonyl chloride (98-74-8) → (6-methyl-2-(4-nitrophenylsulfonamido)pyrimidin-4-yl)trimethylammonium chloride (1421943-67-0)

Guidance literature:

Multi-step reaction with 4 steps

1: pyridine / 100 °C

2: 1.5 h / 170 - 180 °C

3: trichlorophosphate / 0.5 h / Reflux

4: tetrahydrofuran; ethanol / 0.17 h / 0 °C / Sealed tube; Inert atmosphere

With pyridine; trichlorophosphate; In tetrahydrofuran; ethanol;

DOI:10.3998/ark.5550190.0013.914

Reference yield:

N-(4-nitrobenzenesulfonyl)guanidine (42249-51-4) → (6-methyl-2-(4-nitrophenylsulfonamido)pyrimidin-4-yl)trimethylammonium chloride (1421943-67-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.5 h / 170 - 180 °C

2: trichlorophosphate / 0.5 h / Reflux

3: tetrahydrofuran; ethanol / 0.17 h / 0 °C / Sealed tube; Inert atmosphere

With trichlorophosphate; In tetrahydrofuran; ethanol;

DOI:10.3998/ark.5550190.0013.914

upstream raw materials:

N-(4-chloro-6-methylpyrimidin-2-yl)-4-nitrobenzenesulfonamide

trimethylamine

N-(4-nitrobenzenesulfonyl)guanidine

N-(4-hydroxy-6-methylpyrimidin-2-yl)-4-nitrobenzenesulfonamide