but-2-enoic acid 2-[2-((tert-butyldimethylsilanyloxy)methyl)phenyl]ethyl ester

Base Information

• Chemical Name: but-2-enoic acid 2-[2-((tert-butyldimethylsilanyloxy)methyl)phenyl]ethyl ester
• CAS No.: 942062-80-8
• Molecular Formula: C₁₉H₃₀O₃Si
• Molecular Weight: 334.531
• Mol file: 942062-80-8.mol

Synonyms:but-2-enoic acid 2-[2-((tert-butyldimethylsilanyloxy)methyl)phenyl]ethyl ester

Chemical Property of but-2-enoic acid 2-[2-((tert-butyldimethylsilanyloxy)methyl)phenyl]ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of but-2-enoic acid 2-[2-((tert-butyldimethylsilanyloxy)methyl)phenyl]ethyl ester

There total 3 articles about but-2-enoic acid 2-[2-((tert-butyldimethylsilanyloxy)methyl)phenyl]ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

2-[2-((tert-butyldimethylsilanyloxy)methyl)phenyl]ethanol (888324-77-4) + trans-crotonic anhydride (623-68-7) → but-2-enoic acid 2-[2-((tert-butyldimethylsilanyloxy)methyl)phenyl]ethyl ester (942062-80-8)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 0 ℃; for 4h;

DOI:10.1021/ol0704901

Reference yield:

2-(2-hydroxyethyl)benzyl alcohol (6346-00-5) → but-2-enoic acid 2-[2-((tert-butyldimethylsilanyloxy)methyl)phenyl]ethyl ester (942062-80-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 12 percent / triethylamine; 4-(dimethylamino)pyridine / CH₂Cl₂ / 14 h

2: 84 percent / triethylamine; 4-(dimethylamino)pyridine / CH₂Cl₂ / 4 h / 0 °C

With dmap; triethylamine; In dichloromethane;

DOI:10.1021/ol0704901

Reference yield:

tert-butyldimethylsilyl chloride (18162-48-6) → but-2-enoic acid 2-[2-((tert-butyldimethylsilanyloxy)methyl)phenyl]ethyl ester (942062-80-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 12 percent / triethylamine; 4-(dimethylamino)pyridine / CH₂Cl₂ / 14 h

2: 84 percent / triethylamine; 4-(dimethylamino)pyridine / CH₂Cl₂ / 4 h / 0 °C

With dmap; triethylamine; In dichloromethane;

DOI:10.1021/ol0704901

upstream raw materials:

2-[2-((tert-butyldimethylsilanyloxy)methyl)phenyl]ethanol

trans-crotonic anhydride

2-(2-hydroxyethyl)benzyl alcohol

tert-butyldimethylsilyl chloride

Downstream raw materials:

but-2-enoic acid 2-(2-hydroxymethylphenyl)ethyl ester

but-2-enoic acid 2-(2-formylphenyl)ethyl ester