(S)-2-(2,2,6,6-tetramethyl-piperidin-1-yloxymethyl)-1-(toluene-4-sulfonyl)-2,3-dihydro-1H-indole

Base Information

Chemical Name:(S)-2-(2,2,6,6-tetramethyl-piperidin-1-yloxymethyl)-1-(toluene-4-sulfonyl)-2,3-dihydro-1H-indole
CAS No.:1094359-10-0
Molecular Formula:C₂₅H₃₄N₂O₃S
Molecular Weight:442.623
Hs Code.:

Synonyms:(S)-2-(2,2,6,6-tetramethyl-piperidin-1-yloxymethyl)-1-(toluene-4-sulfonyl)-2,3-dihydro-1H-indole

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Chemical Property of (S)-2-(2,2,6,6-tetramethyl-piperidin-1-yloxymethyl)-1-(toluene-4-sulfonyl)-2,3-dihydro-1H-indole

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Technology Process of (S)-2-(2,2,6,6-tetramethyl-piperidin-1-yloxymethyl)-1-(toluene-4-sulfonyl)-2,3-dihydro-1H-indole

There total 2 articles about (S)-2-(2,2,6,6-tetramethyl-piperidin-1-yloxymethyl)-1-(toluene-4-sulfonyl)-2,3-dihydro-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 2564-83-2
2,2,6,6-tetramethyl-piperidine-N-oxyl

: 51315-69-6
N-tosyl-o-allylaniline

: 1094359-10-0
(S)-2-(2,2,6,6-tetramethyl-piperidin-1-yloxymethyl)-1-(toluene-4-sulfonyl)-2,3-dihydro-1H-indole

Guidance literature:: With copper(II) bis(trifluoromethanesulfonate); potassium carbonate; (4R,4'R,5S,5'S)-2,2'-(propane-2,2-diyl)bis(4,5-diphenyl-4,5-dihydrooxazole); In α,α,α-trifluorotoluene; at 110 ℃; for 24h; optical yield given as %ee; Inert atmosphere;
DOI:10.1021/ja806585m

Reference yield:

: 2564-83-2
2,2,6,6-tetramethyl-piperidine-N-oxyl

: 51315-69-6
N-tosyl-o-allylaniline

: 1094359-10-0
(S)-2-(2,2,6,6-tetramethyl-piperidin-1-yloxymethyl)-1-(toluene-4-sulfonyl)-2,3-dihydro-1H-indole

: 1094359-65-5
C₂₅H₃₄N₂O₃S

Guidance literature:: With α,α,α-trifluorotoluene; C₂₃H₂₆N₂O₄; copper(II) bis(trifluoromethanesulfonate); potassium carbonate; at 110 ℃; for 6h; Overall yield = 85 %; enantioselective reaction;
DOI:10.1021/jo3023632