2-chloro-N'-(2-chloroacetyl)-3,4-bis((4-methoxybenzyl)oxy)benzohydrazide

Base Information

Chemical Name:2-chloro-N'-(2-chloroacetyl)-3,4-bis((4-methoxybenzyl)oxy)benzohydrazide
CAS No.:1338705-64-8
Molecular Formula:C₂₅H₂₄Cl₂N₂O₆
Molecular Weight:519.381
Hs Code.:

Synonyms:2-chloro-N'-(2-chloroacetyl)-3,4-bis((4-methoxybenzyl)oxy)benzohydrazide

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Chemical Property of 2-chloro-N'-(2-chloroacetyl)-3,4-bis((4-methoxybenzyl)oxy)benzohydrazide

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Technology Process of 2-chloro-N'-(2-chloroacetyl)-3,4-bis((4-methoxybenzyl)oxy)benzohydrazide

There total 7 articles about 2-chloro-N'-(2-chloroacetyl)-3,4-bis((4-methoxybenzyl)oxy)benzohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1338705-63-7
2-chloro-3,4-bis((4-methoxybenzyl)oxy)benzohydrazide

: 79-04-9
chloroacetyl chloride

: 1338705-64-8
2-chloro-N'-(2-chloroacetyl)-3,4-bis((4-methoxybenzyl)oxy)benzohydrazide

Guidance literature:: With sodium hydrogencarbonate; at 20 ℃; for 0.75h;

Reference yield:

: 1338705-62-6
C₂₇H₂₄ClNO₈

: 1338705-64-8
2-chloro-N'-(2-chloroacetyl)-3,4-bis((4-methoxybenzyl)oxy)benzohydrazide

Guidance literature:: Multi-step reaction with 2 steps

1: hydrazine hydrate / N,N-dimethyl-formamide / 14 h / 20 °C

2: sodium hydrogencarbonate / 0.75 h / 20 °C

With sodium hydrogencarbonate; hydrazine hydrate; In N,N-dimethyl-formamide;

Reference yield:

: 52009-53-7
2-chloro-3,4-dimethoxy-benzoic acid

: 1338705-64-8
2-chloro-N'-(2-chloroacetyl)-3,4-bis((4-methoxybenzyl)oxy)benzohydrazide

Guidance literature:: Multi-step reaction with 6 steps

1.1: boron tribromide / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

1.2: Inert atmosphere

2.1: potassium carbonate; sodium iodide / N,N-dimethyl-formamide / 3.5 h / 50 °C / Inert atmosphere

3.1: sodium hydroxide / tetrahydrofuran; methanol / 1.5 h / Reflux; Inert atmosphere

4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0 - 20 °C

5.1: hydrazine hydrate / N,N-dimethyl-formamide / 14 h / 20 °C / Inert atmosphere

6.1: sodium hydrogencarbonate / N,N-dimethyl-formamide / 0.75 h / 0 °C / Inert atmosphere

With boron tribromide; sodium hydrogencarbonate; potassium carbonate; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium iodide; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2018.06.014