ethyl 5-(4-(trifluoromethyl)phenyl)-1,6-naphthyridine-6(5H)-carboxylate

Base Information

Chemical Name:ethyl 5-(4-(trifluoromethyl)phenyl)-1,6-naphthyridine-6(5H)-carboxylate
CAS No.:1133853-45-8
Molecular Formula:C₁₈H₁₅F₃N₂O₂
Molecular Weight:348.325
Hs Code.:

Synonyms:ethyl 5-(4-(trifluoromethyl)phenyl)-1,6-naphthyridine-6(5H)-carboxylate

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Chemical Property of ethyl 5-(4-(trifluoromethyl)phenyl)-1,6-naphthyridine-6(5H)-carboxylate

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Technology Process of ethyl 5-(4-(trifluoromethyl)phenyl)-1,6-naphthyridine-6(5H)-carboxylate

There total 2 articles about ethyl 5-(4-(trifluoromethyl)phenyl)-1,6-naphthyridine-6(5H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.9%

: 253-72-5
1,6-naphthyridine

: 402-43-7
p-trifluoromethylphenyl bromide

: 541-41-3
chloroformic acid ethyl ester

: 1133853-45-8
ethyl 5-(4-(trifluoromethyl)phenyl)-1,6-naphthyridine-6(5H)-carboxylate

Guidance literature:: p-trifluoromethylphenyl bromide; With iodine; magnesium; In tetrahydrofuran; at 20 ℃;

1,6-naphthyridine; chloroformic acid ethyl ester; In tetrahydrofuran; at 0 - 20 ℃; for 2h; Inert atmosphere;
DOI:10.1021/jm401955h

Reference yield:

: 253-72-5
1,6-naphthyridine

: 402-51-7
4-(trifluoromethyl)phenylmagnesium bromide

: 541-41-3
chloroformic acid ethyl ester

: 1133853-45-8
ethyl 5-(4-(trifluoromethyl)phenyl)-1,6-naphthyridine-6(5H)-carboxylate

Guidance literature:: 1,6-naphthyridine; chloroformic acid ethyl ester; In tetrahydrofuran; at 20 ℃; for 0.25h;

4-(trifluoromethyl)phenylmagnesium bromide; In tetrahydrofuran; at 0 - 20 ℃; for 2h;