1-(6-(biphenyl-4-ylmethoxy)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)-N,N-dimethylmethanamine

Base Information

• Chemical Name: 1-(6-(biphenyl-4-ylmethoxy)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)-N,N-dimethylmethanamine
• CAS No.: 1316314-54-1
• Molecular Formula: C₂₄H₂₅NO₃
• Molecular Weight: 375.467
• Mol file: 1316314-54-1.mol

Synonyms:1-(6-(biphenyl-4-ylmethoxy)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)-N,N-dimethylmethanamine

Chemical Property of 1-(6-(biphenyl-4-ylmethoxy)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)-N,N-dimethylmethanamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(6-(biphenyl-4-ylmethoxy)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)-N,N-dimethylmethanamine

There total 7 articles about 1-(6-(biphenyl-4-ylmethoxy)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)-N,N-dimethylmethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-benzoxy-salicylaldehyde (52085-14-0) → 1-(6-(biphenyl-4-ylmethoxy)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)-N,N-dimethylmethanamine (1316314-54-1)

Guidance literature:

Multi-step reaction with 7 steps

1: piperidine / 4 h / 100 °C

2: potassium hydrogensulfate; dihydrogen peroxide / methanol / 20 °C

3: potassium hydroxide / 1 h / 20 °C

4: palladium 10% on activated carbon; hydrogen / ethanol; ethyl acetate / 5 h

5: potassium carbonate; potassium iodide / acetonitrile / 60 - 80 °C

6: 1H-imidazole; iodine; triphenylphosphine / tetrahydrofuran / 5 h / 20 °C

7: iodine; potassium carbonate / tetrahydrofuran / 3 h / 20 °C

With piperidine; 1H-imidazole; potassium hydrogensulfate; palladium 10% on activated carbon; hydrogen; dihydrogen peroxide; iodine; potassium carbonate; triphenylphosphine; potassium iodide; potassium hydroxide; In tetrahydrofuran; methanol; ethanol; ethyl acetate; acetonitrile; 2: Baeyer-Villiger oxidation;

DOI:10.2174/157018010791526304

Reference yield:

6-(biphenyl-4-ylmethoxy)-2-(iodomethyl)-2,3-dihydrobenzo[b][1,4]dioxine + dimethyl amine (124-40-3) → 1-(6-(biphenyl-4-ylmethoxy)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)-N,N-dimethylmethanamine (1316314-54-1)

Guidance literature:

With iodine; potassium carbonate; In tetrahydrofuran; at 20 ℃; for 3h;

DOI:10.2174/157018010791526304

Reference yield:

4-(benzyloxy)-2-(3-chloro-2-hydroxypropoxy)phenol (1316314-51-8) → 1-(6-(biphenyl-4-ylmethoxy)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)-N,N-dimethylmethanamine (1316314-54-1)

Guidance literature:

Multi-step reaction with 5 steps

1: potassium hydroxide / 1 h / 20 °C

2: palladium 10% on activated carbon; hydrogen / ethanol; ethyl acetate / 5 h

3: potassium carbonate; potassium iodide / acetonitrile / 60 - 80 °C

4: 1H-imidazole; iodine; triphenylphosphine / tetrahydrofuran / 5 h / 20 °C

5: iodine; potassium carbonate / tetrahydrofuran / 3 h / 20 °C

With 1H-imidazole; palladium 10% on activated carbon; hydrogen; iodine; potassium carbonate; triphenylphosphine; potassium iodide; potassium hydroxide; In tetrahydrofuran; ethanol; ethyl acetate; acetonitrile;

DOI:10.2174/157018010791526304

upstream raw materials:

4-(benzyloxy)-2-(3-chloro-2-hydroxypropoxy)benzaldehyde

4-(benzyloxy)-2-(3-chloro-2-hydroxypropoxy)phenol

(6-(benzyloxy)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methanol

2-(hydroxymethyl)-2,3-dihydrobenzo[b][1,4]dioxin-6-ol