N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)ethyl]-N-phenylacetamide

Base Information

Chemical Name:N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)ethyl]-N-phenylacetamide
CAS No.:1313602-61-7
Molecular Formula:C₂₃H₂₉NO₂
Molecular Weight:351.489
Hs Code.:

Synonyms:N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)ethyl]-N-phenylacetamide

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Chemical Property of N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)ethyl]-N-phenylacetamide

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Technology Process of N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)ethyl]-N-phenylacetamide

There total 6 articles about N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)ethyl]-N-phenylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 1313602-62-8
N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)ethyl]aniline

: 75-36-5
acetyl chloride

: 1313602-61-7
N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)ethyl]-N-phenylacetamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 1h;
DOI:10.1021/jm200249a

Reference yield:

: 1194-16-7
2,2-dimethyltetrahydropyran-4-one

: 1313602-61-7
N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)ethyl]-N-phenylacetamide

Guidance literature:: Multi-step reaction with 6 steps

1: ammonium acetate / toluene / Reflux; Dean-Stark trap

2: copper(I) bromide dimethylsulfide complex / tetrahydrofuran / -78 - 20 °C

3: potassium hydroxide / ethylene glycol / 1.5 h / 190 °C

4: lithium aluminium tetrahydride / diethyl ether / 2 h / 0 - 20 °C

5: copper diacetate; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

6: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C

With lithium aluminium tetrahydride; copper(I) bromide dimethylsulfide complex; ammonium acetate; copper diacetate; N-ethyl-N,N-diisopropylamine; potassium hydroxide; In tetrahydrofuran; diethyl ether; dichloromethane; ethylene glycol; toluene;
DOI:10.1021/jm200249a

Reference yield:

: 64792-49-0
Ethyl (2,2-dimethyl-4-tetrahydropyranylidene)cyanoacetate

: 1313602-61-7
N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)ethyl]-N-phenylacetamide

Guidance literature:: Multi-step reaction with 5 steps

1: copper(I) bromide dimethylsulfide complex / tetrahydrofuran / -78 - 20 °C

2: potassium hydroxide / ethylene glycol / 1.5 h / 190 °C

3: lithium aluminium tetrahydride / diethyl ether / 2 h / 0 - 20 °C

4: copper diacetate; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

5: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C

With lithium aluminium tetrahydride; copper(I) bromide dimethylsulfide complex; copper diacetate; N-ethyl-N,N-diisopropylamine; potassium hydroxide; In tetrahydrofuran; diethyl ether; dichloromethane; ethylene glycol;
DOI:10.1021/jm200249a