N-(2,6-dimethoxy-pyrimidin-4-yl)-4-nitro-benzenesulfonamide

Base Information

• Chemical Name: N-(2,6-dimethoxy-pyrimidin-4-yl)-4-nitro-benzenesulfonamide
• CAS No.: 37063-70-0
• Molecular Formula: C₁₂H₁₂N₄O₆S
• Molecular Weight: 340.316
• Mol file: 37063-70-0.mol

Synonyms:N-(2,6-dimethoxy-pyrimidin-4-yl)-4-nitro-benzenesulfonamide

Chemical Property of N-(2,6-dimethoxy-pyrimidin-4-yl)-4-nitro-benzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(2,6-dimethoxy-pyrimidin-4-yl)-4-nitro-benzenesulfonamide

There total 3 articles about N-(2,6-dimethoxy-pyrimidin-4-yl)-4-nitro-benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.2%

2,6-dimethoxypyrimidin-4-amine (3289-50-7) + 4-Nitrobenzenesulfonyl chloride (98-74-8) → N-(2,6-dimethoxy-pyrimidin-4-yl)-4-nitro-benzenesulfonamide (37063-70-0)

Guidance literature:

With pyridine; at 56 - 58 ℃; for 2h;

DOI:10.1007/BF01156380

Reference yield:

4-nitrobenzenediazonium chloride (100-05-0) → N-(2,6-dimethoxy-pyrimidin-4-yl)-4-nitro-benzenesulfonamide (37063-70-0)

Guidance literature:

Multi-step reaction with 2 steps

1: SO₂ / CuSO₄ / acetic acid / 6 - 20 °C

2: 84.2 percent / pyridine / 2 h / 56 - 58 °C

With pyridine; sulfur dioxide; copper(II) sulfate; In acetic acid;

DOI:10.1007/BF01156380

Reference yield:

→ N-(2,6-dimethoxy-pyrimidin-4-yl)-4-nitro-benzenesulfonamide (37063-70-0)

Guidance literature:

4-Amino-2,6-dimethoxy-pyrimidin, p-Nitro-benzolsulfonsaeurechlorid, Py., 50-60grad, 30 min;

upstream raw materials:

2,6-dimethoxypyrimidin-4-amine

4-Nitrobenzenesulfonyl chloride

4-nitrobenzenediazonium chloride

Downstream raw materials:

sulfadimethoxine