5-(4-(isopropylsulfonyl)phenyl)-3-(3-(4-((oxetan-3-ylmethylamino)methyl)phenyl)isoxazol-5-yl)pyrazin-2-amine

Base Information

Chemical Name:5-(4-(isopropylsulfonyl)phenyl)-3-(3-(4-((oxetan-3-ylmethylamino)methyl)phenyl)isoxazol-5-yl)pyrazin-2-amine
CAS No.:1429241-65-5
Molecular Formula:C₂₇H₂₉N₅O₄S
Molecular Weight:519.624
Hs Code.:

Synonyms:5-(4-(isopropylsulfonyl)phenyl)-3-(3-(4-((oxetan-3-ylmethylamino)methyl)phenyl)isoxazol-5-yl)pyrazin-2-amine

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Chemical Property of 5-(4-(isopropylsulfonyl)phenyl)-3-(3-(4-((oxetan-3-ylmethylamino)methyl)phenyl)isoxazol-5-yl)pyrazin-2-amine

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Technology Process of 5-(4-(isopropylsulfonyl)phenyl)-3-(3-(4-((oxetan-3-ylmethylamino)methyl)phenyl)isoxazol-5-yl)pyrazin-2-amine

There total 5 articles about 5-(4-(isopropylsulfonyl)phenyl)-3-(3-(4-((oxetan-3-ylmethylamino)methyl)phenyl)isoxazol-5-yl)pyrazin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 850567-98-5
4-(isopropylsulfonyl)phenylboronic acid

: 1349734-97-9
5-bromo-3-(3-(4-(chloromethyl)phenyl)isoxazol-5-yl)pyrazin-2-amine

: 6246-05-5
1-(oxetan-3-yl)methanamine

: 1429241-65-5
5-(4-(isopropylsulfonyl)phenyl)-3-(3-(4-((oxetan-3-ylmethylamino)methyl)phenyl)isoxazol-5-yl)pyrazin-2-amine

Guidance literature:: 5-bromo-3-(3-(4-(chloromethyl)phenyl)isoxazol-5-yl)pyrazin-2-amine; 1-(oxetan-3-yl)methanamine; With N-ethyl-N,N-diisopropylamine; In ethanol; at 120 ℃; for 0.5h;

4-(isopropylsulfonyl)phenylboronic acid; With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; toluene; at 90 ℃; for 0.5h;

Reference yield:

: 99848-46-1
4-(chloromethyl)benzaldehyde oxime

: 1429241-65-5
5-(4-(isopropylsulfonyl)phenyl)-3-(3-(4-((oxetan-3-ylmethylamino)methyl)phenyl)isoxazol-5-yl)pyrazin-2-amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-chloro-succinimide; hydrogenchloride / N,N-dimethyl-formamide; 1,4-dioxane-d8 / 1 h / 20 °C / Cooling with ice

2.1: triethylamine / dichloromethane / 20 °C

2.2: 0.25 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine / ethanol / 0.5 h / 120 °C

3.2: 0.5 h / 90 °C

With hydrogenchloride; N-chloro-succinimide; triethylamine; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane-d8; ethanol; dichloromethane; N,N-dimethyl-formamide; 3.2: |Suzuki Coupling;

Reference yield:

: 73291-09-5
4-chloromethylbenzaldehyde

: 1429241-65-5
5-(4-(isopropylsulfonyl)phenyl)-3-(3-(4-((oxetan-3-ylmethylamino)methyl)phenyl)isoxazol-5-yl)pyrazin-2-amine

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydroxylamine hydrochloride / ethanol / 3 h / 50 °C

2.1: N-chloro-succinimide; hydrogenchloride / N,N-dimethyl-formamide; 1,4-dioxane-d8 / 1 h / 20 °C / Cooling with ice

3.1: triethylamine / dichloromethane / 20 °C

3.2: 0.25 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine / ethanol / 0.5 h / 120 °C

4.2: 0.5 h / 90 °C

With hydrogenchloride; N-chloro-succinimide; hydroxylamine hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane-d8; ethanol; dichloromethane; N,N-dimethyl-formamide; 4.2: |Suzuki Coupling;