(+)-(R)-S-(1-Benzoyl-1-phenylethyl)-(2,2,4,4-tetramethyl-1,3-oxazolidine-3-carbonylthiocarboxylate)

Base Information

Chemical Name:(+)-(R)-S-(1-Benzoyl-1-phenylethyl)-(2,2,4,4-tetramethyl-1,3-oxazolidine-3-carbonylthiocarboxylate)
CAS No.:334757-24-3
Molecular Formula:C₂₃H₂₇NO₃S
Molecular Weight:397.538
Hs Code.:

Synonyms:(+)-(R)-S-(1-Benzoyl-1-phenylethyl)-(2,2,4,4-tetramethyl-1,3-oxazolidine-3-carbonylthiocarboxylate)

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Chemical Property of (+)-(R)-S-(1-Benzoyl-1-phenylethyl)-(2,2,4,4-tetramethyl-1,3-oxazolidine-3-carbonylthiocarboxylate)

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Technology Process of (+)-(R)-S-(1-Benzoyl-1-phenylethyl)-(2,2,4,4-tetramethyl-1,3-oxazolidine-3-carbonylthiocarboxylate)

There total 5 articles about (+)-(R)-S-(1-Benzoyl-1-phenylethyl)-(2,2,4,4-tetramethyl-1,3-oxazolidine-3-carbonylthiocarboxylate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 98-88-4
benzoyl chloride

: 334757-17-4
(-)-(S)-S-Phenylethyl 2,2,4,4-tetramethyl-1,3-oxazolidine-3-thiocarboxylate

: 334757-24-3
(+)-(R)-S-(1-Benzoyl-1-phenylethyl)-(2,2,4,4-tetramethyl-1,3-oxazolidine-3-carbonylthiocarboxylate)

Guidance literature:: (-)-(S)-S-Phenylethyl 2,2,4,4-tetramethyl-1,3-oxazolidine-3-thiocarboxylate; With N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; In diethyl ether; cyclohexane; at -78 ℃; for 2h;

benzoyl chloride; In diethyl ether; cyclohexane; at -78 ℃; Further stages.;
DOI:10.1002/1521-3765(20010119)7:2<423::AID-CHEM423>3.0.CO;2-Y

Reference yield: 91.0%

: (2R)-1,2-Diphenyl-2-(2,2,4,4-tetramethyl-1,3-oxazolidine-3-carbonylthio)-1-propanol

: 334757-24-3
(+)-(R)-S-(1-Benzoyl-1-phenylethyl)-(2,2,4,4-tetramethyl-1,3-oxazolidine-3-carbonylthiocarboxylate)

Guidance literature:: With oxalyl dichloride; dimethyl sulfoxide; triethylamine; In dichloromethane; at -78 - 20 ℃;
DOI:10.1002/1521-3765(20010119)7:2<423::AID-CHEM423>3.0.CO;2-Y

Reference yield:

: 33877-11-1
(S)-1-mercapto-1-phenylethane

: 334757-24-3
(+)-(R)-S-(1-Benzoyl-1-phenylethyl)-(2,2,4,4-tetramethyl-1,3-oxazolidine-3-carbonylthiocarboxylate)

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaH / tetrahydrofuran / 0.5 h / 20 °C

1.2: 97 percent / tetrahydrofuran / 3 h / Heating

2.1: TMEDA; sec-BuLi / diethyl ether; cyclohexane / 2 h / -78 °C

2.2: 92 percent / diethyl ether; cyclohexane / -78 °C

With N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; sodium hydride; In tetrahydrofuran; diethyl ether; cyclohexane;
DOI:10.1002/1521-3765(20010119)7:2<423::AID-CHEM423>3.0.CO;2-Y