2-chloro-6-(3,5-dimethoxyphenyl)quinazoline

Base Information

• Chemical Name: 2-chloro-6-(3,5-dimethoxyphenyl)quinazoline
• CAS No.: 1538605-05-8
• Molecular Formula: C₁₆H₁₃ClN₂O₂
• Molecular Weight: 300.744
• Mol file: 1538605-05-8.mol

Synonyms:

Chemical Property of 2-chloro-6-(3,5-dimethoxyphenyl)quinazoline

Chemical Property:

• Boiling Point: 430.7±45.0 °C(Predicted)
• PKA: -0.12±0.30(Predicted)
• Density: 1.278±0.06 g/cm3(Predicted)

Purity/Quality:

99% ^*data from raw suppliers

2-Chloro-6-(3,5-dimethoxyphenyl)quinazoline 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-chloro-6-(3,5-dimethoxyphenyl)quinazoline

There total 5 articles about 2-chloro-6-(3,5-dimethoxyphenyl)quinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

6-bromo-2-chloroquinazoline (882672-05-1) + 3,5-dimethoxyphenylboronic acid (192182-54-0) → 2-chloro-6-(3,5-dimethoxyphenyl)quinazoline (1538605-05-8)

Guidance literature:

With [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II); Cs₂CO₃; In tetrahydrofuran; water monomer; for 4h; Reflux; Inert atmosphere;

Reference yield:

5-Bromo-2-aminobenzoic acid (5794-88-7) → 2-chloro-6-(3,5-dimethoxyphenyl)quinazoline (1538605-05-8)

Guidance literature:

Multi-step reaction with 5 steps

1: borane-THF / tetrahydrofuran / 0 - 20 °C

2: manganese(IV) oxide / dichloromethane / 20 °C

3: neat (no solvent) / 5 h / 180 °C

4: trichlorophosphate / 5 h / 110 °C

5: caesium carbonate; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran; water; 1,4-dioxane / 3 h / 80 °C / Inert atmosphere; Microwave irradiation

With manganese(IV) oxide; bis-triphenylphosphine-palladium(II) chloride; borane-THF; caesium carbonate; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water;

Reference yield:

(2-amino-5-bromophenyl)methanol (20712-12-3) → 2-chloro-6-(3,5-dimethoxyphenyl)quinazoline (1538605-05-8)

Guidance literature:

Multi-step reaction with 4 steps

1: manganese(IV) oxide / dichloromethane / 20 °C

2: neat (no solvent) / 5 h / 180 °C

3: trichlorophosphate / 5 h / 110 °C

4: caesium carbonate; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran; water; 1,4-dioxane / 3 h / 80 °C / Inert atmosphere; Microwave irradiation

With manganese(IV) oxide; bis-triphenylphosphine-palladium(II) chloride; caesium carbonate; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water;

upstream raw materials:

5-Bromo-2-aminobenzoic acid

(2-amino-5-bromophenyl)methanol

2-amino-5-bromobenzaldehyde

6-bromoquinazolin-2-ol

Downstream raw materials:

2-chloro-6-(2,6-dichloro-3,5-dimethoxyphenyl)quinazoline

6-(2,6-dichloro-3,5-dimethoxyphenyl)-N-(2-methyl-6-nitrophenyl)quinazolin-2-amine

BLU9931