(1aS,2S,3aS,5R,7aR,7bR)-2-Hydroxymethyl-5-phenyl-hexahydro-1,4,6-trioxa-cyclopropa[a]naphthalene-3a-carboxylic acid methyl ester

Base Information

Chemical Name:(1aS,2S,3aS,5R,7aR,7bR)-2-Hydroxymethyl-5-phenyl-hexahydro-1,4,6-trioxa-cyclopropa[a]naphthalene-3a-carboxylic acid methyl ester
CAS No.:198289-38-2
Molecular Formula:C₁₇H₂₀O₆
Molecular Weight:320.342
Hs Code.:

Synonyms:(1aS,2S,3aS,5R,7aR,7bR)-2-Hydroxymethyl-5-phenyl-hexahydro-1,4,6-trioxa-cyclopropa[a]naphthalene-3a-carboxylic acid methyl ester

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Chemical Property of (1aS,2S,3aS,5R,7aR,7bR)-2-Hydroxymethyl-5-phenyl-hexahydro-1,4,6-trioxa-cyclopropa[a]naphthalene-3a-carboxylic acid methyl ester

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Technology Process of (1aS,2S,3aS,5R,7aR,7bR)-2-Hydroxymethyl-5-phenyl-hexahydro-1,4,6-trioxa-cyclopropa[a]naphthalene-3a-carboxylic acid methyl ester

There total 10 articles about (1aS,2S,3aS,5R,7aR,7bR)-2-Hydroxymethyl-5-phenyl-hexahydro-1,4,6-trioxa-cyclopropa[a]naphthalene-3a-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 198289-36-0
(2R,4aS,7R,8aS)-7-Hydroxymethyl-2-phenyl-4,4a,7,8-tetrahydro-benzo[1,3]dioxine-8a-carboxylic acid methyl ester

: (1aR,2S,3aS,5R,7aR,7bS)-2-Hydroxymethyl-5-phenyl-hexahydro-1,4,6-trioxa-cyclopropa[a]naphthalene-3a-carboxylic acid methyl ester

: 198289-38-2
(1aS,2S,3aS,5R,7aR,7bR)-2-Hydroxymethyl-5-phenyl-hexahydro-1,4,6-trioxa-cyclopropa[a]naphthalene-3a-carboxylic acid methyl ester

Guidance literature:: With sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; In dichloromethane;
DOI:10.1021/jo970960c

Reference yield:

: (2S,3aS,5R,7aR)-2-Acetoxymethyl-5-phenyl-hexahydro-1,4,6-trioxa-cyclopropa[a]naphthalene-3a-carboxylic acid methyl ester

: 198289-38-2
(1aS,2S,3aS,5R,7aR,7bR)-2-Hydroxymethyl-5-phenyl-hexahydro-1,4,6-trioxa-cyclopropa[a]naphthalene-3a-carboxylic acid methyl ester

Guidance literature:: With potassium carbonate; In methanol; at 0 ℃; for 1.5h;
DOI:10.1021/jo970960c

Reference yield:

: 107550-83-4
(2E,4E)-hexa-2,4-diene-1,6-diol

: 198289-38-2
(1aS,2S,3aS,5R,7aR,7bR)-2-Hydroxymethyl-5-phenyl-hexahydro-1,4,6-trioxa-cyclopropa[a]naphthalene-3a-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 95 percent / imidazole / dimethylformamide / 48 h / Ambient temperature

2: 35 percent / BHT / 42 h / 150 °C

3: 88 percent / HF*Et₃N / acetonitrile / 42 h / 40 °C

4: 91 percent / K₂CO₃ / 1 h / Ambient temperature

5: 64 percent / ZnCl₂ / diethyl ether / 1 h / Ambient temperature

6: 95 percent / pyridine / 20 h / Ambient temperature

7: 173 mg / MCPBA, NaHCO₃ / CHCl₃ / 18 h / Ambient temperature

8: 112 mg / K₂CO₃ / methanol / 1.5 h / 0 °C

With 1H-imidazole; 2,6-di-tert-butyl-4-methyl-phenol; sodium hydrogencarbonate; potassium carbonate; triethylamine hydrofluoride; 3-chloro-benzenecarboperoxoic acid; zinc(II) chloride; In pyridine; methanol; diethyl ether; chloroform; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jo970960c