(S)-N-(9-(4-(bis(4-methoxyphenyl)(phenyl)methoxy)-2-hydroxybutyl)-9H-purin-6-yl)benzamide

Base Information

Chemical Name:(S)-N-(9-(4-(bis(4-methoxyphenyl)(phenyl)methoxy)-2-hydroxybutyl)-9H-purin-6-yl)benzamide
CAS No.:1452390-88-3
Molecular Formula:C₃₇H₃₅N₅O₅
Molecular Weight:629.715
Hs Code.:

Synonyms:(S)-N-(9-(4-(bis(4-methoxyphenyl)(phenyl)methoxy)-2-hydroxybutyl)-9H-purin-6-yl)benzamide

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Chemical Property of (S)-N-(9-(4-(bis(4-methoxyphenyl)(phenyl)methoxy)-2-hydroxybutyl)-9H-purin-6-yl)benzamide

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Technology Process of (S)-N-(9-(4-(bis(4-methoxyphenyl)(phenyl)methoxy)-2-hydroxybutyl)-9H-purin-6-yl)benzamide

There total 2 articles about (S)-N-(9-(4-(bis(4-methoxyphenyl)(phenyl)methoxy)-2-hydroxybutyl)-9H-purin-6-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1452390-87-2
(S)-1-(6-amino-9H-purin-9-yl)-4-(bis(4-methoxyphenyl)-(phenyl)methoxy)butan-2-ol

: 98-88-4
benzoyl chloride

: 1452390-88-3
(S)-N-(9-(4-(bis(4-methoxyphenyl)(phenyl)methoxy)-2-hydroxybutyl)-9H-purin-6-yl)benzamide

Guidance literature:: (S)-1-(6-amino-9H-purin-9-yl)-4-(bis(4-methoxyphenyl)-(phenyl)methoxy)butan-2-ol; With pyridine; chloro-trimethyl-silane; at 0 - 20 ℃; for 4.5h; Inert atmosphere;

benzoyl chloride; at 0 - 20 ℃; for 4h;
DOI:10.1039/c3ob41244j

Reference yield:

: 1452390-84-9
(S)-2-(2-(bis(4-methoxyphenyl)(phenyl)methoxy)ethyl)oxirane

: 1452390-88-3
(S)-N-(9-(4-(bis(4-methoxyphenyl)(phenyl)methoxy)-2-hydroxybutyl)-9H-purin-6-yl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 20 °C

1.2: 12 h / 110 °C

2.1: pyridine; chloro-trimethyl-silane / 4.5 h / 0 - 20 °C / Inert atmosphere

2.2: 4 h / 0 - 20 °C

With pyridine; chloro-trimethyl-silane; sodium hydride; In N,N-dimethyl-formamide;
DOI:10.1039/c3ob41244j

Reference yield: 67.0%

: 1452390-88-3
(S)-N-(9-(4-(bis(4-methoxyphenyl)(phenyl)methoxy)-2-hydroxybutyl)-9H-purin-6-yl)benzamide

: 102691-36-1
N,N,N',N'-tetraisopropyl 2-cyanoethylphosphorodiamidite

: 1452390-98-5,1452390-99-6
C₄₆H₅₂N₇O₆P

Guidance literature:: (S)-N-(9-(4-(bis(4-methoxyphenyl)(phenyl)methoxy)-2-hydroxybutyl)-9H-purin-6-yl)benzamide; With diisopropylammonium tetrazolide; In dichloromethane; for 0.0166667h; Inert atmosphere;

N,N,N',N'-tetraisopropyl 2-cyanoethylphosphorodiamidite; In dichloromethane; at 20 ℃; for 3h; Inert atmosphere;
DOI:10.1039/c3ob41244j