N-(adamantan-1-yl)-2,4,6-trimethylbenzamide

Base Information

• Chemical Name: N-(adamantan-1-yl)-2,4,6-trimethylbenzamide
• CAS No.: 1402047-66-8
• Molecular Formula: C₂₀H₂₇NO
• Molecular Weight: 297.44
• Mol file: 1402047-66-8.mol

Synonyms:N-(adamantan-1-yl)-2,4,6-trimethylbenzamide

Chemical Property of N-(adamantan-1-yl)-2,4,6-trimethylbenzamide

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of N-(adamantan-1-yl)-2,4,6-trimethylbenzamide

There total 3 articles about N-(adamantan-1-yl)-2,4,6-trimethylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

S-phenyl (1-adamantyl)thiocarbamate + 2-mesitylmagnesium bromide (2633-66-1) → N-(adamantan-1-yl)-2,4,6-trimethylbenzamide (1402047-66-8) + diphenyldisulfane (882-33-7)

Guidance literature:

S-phenyl (1-adamantyl)thiocarbamate; 2-mesitylmagnesium bromide; In 2-methyltetrahydrofuran; at 0 - 20 ℃; for 2h; Schlenk technique; Inert atmosphere; Large scale;

With ammonium hydroxide; oxygen; In 2-methyltetrahydrofuran; for 18h; Inert atmosphere; Large scale;

DOI:10.1021/acs.orglett.8b01654

Reference yield: 87.0%

1-adamantyl isocyanate (4411-25-0) + 2-mesitylmagnesium bromide (2633-66-1) → N-(adamantan-1-yl)-2,4,6-trimethylbenzamide (1402047-66-8)

Guidance literature:

1-adamantyl isocyanate; 2-mesitylmagnesium bromide; In diethyl ether; at 0 - 20 ℃; Inert atmosphere;

With water; ammonium chloride; In diethyl ether;

DOI:10.1002/anie.201204481

Reference yield:

1-Adamantanamine (768-94-5) + 2,4,6-trimethylbenzoyl fluoride (826-66-4) → N-(adamantan-1-yl)-2,4,6-trimethylbenzamide (1402047-66-8)

Guidance literature:

In dichloromethane; at 80 ℃; for 24h; Inert atmosphere; Sealed tube;

DOI:10.1039/c5ob02129d

upstream raw materials:

1-adamantyl isocyanate

2-mesitylmagnesium bromide

1-Adamantanamine

2,4,6-trimethylbenzoyl fluoride