methyl 3-bromo-6-chloro-4-[(2,4-dimethoxyphenyl)methylamino]pyridine-2-carboxylate

Base Information

Chemical Name:methyl 3-bromo-6-chloro-4-[(2,4-dimethoxyphenyl)methylamino]pyridine-2-carboxylate
CAS No.:1350828-29-3
Molecular Formula:C₁₆H₁₆BrClN₂O₄
Molecular Weight:415.671
Hs Code.:

Synonyms:methyl 3-bromo-6-chloro-4-[(2,4-dimethoxyphenyl)methylamino]pyridine-2-carboxylate

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Chemical Property of methyl 3-bromo-6-chloro-4-[(2,4-dimethoxyphenyl)methylamino]pyridine-2-carboxylate

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Technology Process of methyl 3-bromo-6-chloro-4-[(2,4-dimethoxyphenyl)methylamino]pyridine-2-carboxylate

There total 5 articles about methyl 3-bromo-6-chloro-4-[(2,4-dimethoxyphenyl)methylamino]pyridine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: methyl 3-bromo-4,6-dichloro-pyridine-2-carboxylate

: 20781-20-8
2,4-Dimethoxybenzylamine

: 1350828-29-3
methyl 3-bromo-6-chloro-4-[(2,4-dimethoxyphenyl)methylamino]pyridine-2-carboxylate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; at 80 ℃; for 2.5h;
DOI:10.1021/acsmedchemlett.9b00649

Reference yield:

: 929000-66-8
3-bromo-6-chloropyridine-2-carboxylic acid

: 1350828-29-3
methyl 3-bromo-6-chloro-4-[(2,4-dimethoxyphenyl)methylamino]pyridine-2-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: sulfuric acid / 6 h / Reflux

2: trifluoroacetic anhydride; urea hydrogen peroxide adduct / dichloromethane / 1 h / 0 - 20 °C

3: trichlorophosphate / 4 h / Reflux

4: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 2.5 h / 80 °C

With sulfuric acid; urea hydrogen peroxide adduct; N-ethyl-N,N-diisopropylamine; trifluoroacetic anhydride; trichlorophosphate; In 1-methyl-pyrrolidin-2-one; dichloromethane;
DOI:10.1021/acsmedchemlett.9b00649

Reference yield:

: 1259330-30-7
3-bromo-6-chloro-2-(methoxycarbonyl)pyridine 1-oxide

: 1350828-29-3
methyl 3-bromo-6-chloro-4-[(2,4-dimethoxyphenyl)methylamino]pyridine-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: trichlorophosphate / 4 h / Reflux

2: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 2.5 h / 80 °C

With N-ethyl-N,N-diisopropylamine; trichlorophosphate; In 1-methyl-pyrrolidin-2-one;
DOI:10.1021/acsmedchemlett.9b00649