2-Pyridinecarboxylic acid, 3-broMo-6-chloro-, Methyl ester

Base Information

• Chemical Name: 2-Pyridinecarboxylic acid, 3-broMo-6-chloro-, Methyl ester
• CAS No.: 1214328-96-7
• Molecular Formula: C7H5BrClNO2
• Molecular Weight: 250.479
• Hs Code.: 2933399090
• Mol file: 1214328-96-7.mol

Synonyms:2-Pyridinecarboxylic acid, 3-broMo-6-chloro-, Methyl ester;methyl 3-bromo-6-chloropyridine-2-carboxylate

Chemical Property of 2-Pyridinecarboxylic acid, 3-broMo-6-chloro-, Methyl ester

Chemical Property:

• Boiling Point: 306.8±37.0 °C(Predicted)
• PKA: -3.63±0.10(Predicted)
• PSA: 39.19000
• Density: 1.684±0.06 g/cm3(Predicted)
• LogP: 2.28410
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

Methyl3-bromo-6-chloropicolinate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Pyridinecarboxylic acid, 3-broMo-6-chloro-, Methyl ester

There total 3 articles about 2-Pyridinecarboxylic acid, 3-broMo-6-chloro-, Methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methanol (67-56-1) + 3-bromo-6-chloropyridine-2-carboxylic acid (929000-66-8) → methyl 3-bromo-6-chloro-pyridine-2-carboxylate (1214328-96-7)

Guidance literature:

With sulfuric acid; for 28h; Reflux;

Reference yield: 87.0%

3-bromo-6-chloropyridine-2-carboxylic acid (929000-66-8) → methyl 3-bromo-6-chloro-pyridine-2-carboxylate (1214328-96-7)

Guidance literature:

With thionyl chloride; In ethanol; at 60 ℃;

Reference yield: 41.3%

3-bromo-6-chloropyridine-2-carboxylic acid (929000-66-8) + methyl iodide (74-88-4) → methyl 3-bromo-6-chloro-pyridine-2-carboxylate (1214328-96-7)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

upstream raw materials:

methanol

3-bromo-6-chloropyridine-2-carboxylic acid

methyl iodide

Downstream raw materials:

(3-bromo-6-chloropyridin-2-yl)methanol

3-bromo-6-chloropyridine-2-carbaldehyde

methyl 3-bromo-6-chloro-4-[(2,4-dimethoxyphenyl)methylamino]pyridine-2-carboxylate

methyl 3-bromo-6-methoxypyridine-2-carboxylate

Refernces

• 1、 -. "HPK1 ANTAGONISTS AND USES THEREOF". Paragraph 0853; 0854. . Retrieved 2021/03/19.
• 2、 -. "Novel heterocyclic derivative capable of being used as SHP2 inhibitor". Paragraph 0294. . Retrieved 2019/08/30.