exo-7-[(1S,3S,5R)-(8-aza-bicyclo[3.2.1]oct-3-yl)oxy]-3-phenyl-chromen-2-one hydrochloride

Base Information

Chemical Name:exo-7-[(1S,3S,5R)-(8-aza-bicyclo[3.2.1]oct-3-yl)oxy]-3-phenyl-chromen-2-one hydrochloride
CAS No.:1034815-39-8
Molecular Formula:C₂₂H₂₁NO₃*ClH
Molecular Weight:383.875
Hs Code.:

Synonyms:exo-7-[(1S,3S,5R)-(8-aza-bicyclo[3.2.1]oct-3-yl)oxy]-3-phenyl-chromen-2-one hydrochloride

Suppliers and Price of exo-7-[(1S,3S,5R)-(8-aza-bicyclo[3.2.1]oct-3-yl)oxy]-3-phenyl-chromen-2-one hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of exo-7-[(1S,3S,5R)-(8-aza-bicyclo[3.2.1]oct-3-yl)oxy]-3-phenyl-chromen-2-one hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of exo-7-[(1S,3S,5R)-(8-aza-bicyclo[3.2.1]oct-3-yl)oxy]-3-phenyl-chromen-2-one hydrochloride

There total 10 articles about exo-7-[(1S,3S,5R)-(8-aza-bicyclo[3.2.1]oct-3-yl)oxy]-3-phenyl-chromen-2-one hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₇H₂₉NO₅

: 1034815-39-8
exo-7-[(1S,3S,5R)-(8-aza-bicyclo[3.2.1]oct-3-yl)oxy]-3-phenyl-chromen-2-one hydrochloride

Guidance literature:: With hydrogenchloride; acetic acid; for 3h;

Reference yield:

: endo-3-benzoyloxy-8-aza-bicyclo[3.2.1]octane-8-carboxylic acid trichloromethyl ester

: 1034815-39-8
exo-7-[(1S,3S,5R)-(8-aza-bicyclo[3.2.1]oct-3-yl)oxy]-3-phenyl-chromen-2-one hydrochloride

Guidance literature:: Multi-step reaction with 7 steps

1: acetic acid; zinc / 3 h

2: triethylamine / tetrahydrofuran / 1.5 h / 20 °C

3: potassium hydroxide; ethanol / 72 h / 20 °C

4: triphenylphosphine; diethylazodicarboxylate / 1,4-dioxane / 15.25 h / 8 - 20 °C

5: bromine; sodium acetate; acetic acid / 1.5 h / 20 °C

6: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾; Palladacycle / 1,2-dimethoxyethane; water / 2 h / Heating / reflux

7: hydrogenchloride; acetic acid / 3 h

With hydrogenchloride; potassium hydroxide; ethanol; bromine; sodium acetate; potassium carbonate; acetic acid; triethylamine; triphenylphosphine; zinc; diethylazodicarboxylate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; Palladacycle; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; water;

Reference yield:

: 120-29-6
3-tropanol

: 1034815-39-8
exo-7-[(1S,3S,5R)-(8-aza-bicyclo[3.2.1]oct-3-yl)oxy]-3-phenyl-chromen-2-one hydrochloride

Guidance literature:: Multi-step reaction with 9 steps

1: potassium tert-butylate / tetrahydrofuran / 2.5 h / 20 - 30 °C

2: toluene / 16 h / 20 - 100 °C

3: acetic acid; zinc / 3 h

4: triethylamine / tetrahydrofuran / 1.5 h / 20 °C

5: potassium hydroxide; ethanol / 72 h / 20 °C

6: triphenylphosphine; diethylazodicarboxylate / 1,4-dioxane / 15.25 h / 8 - 20 °C

7: bromine; sodium acetate; acetic acid / 1.5 h / 20 °C

8: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾; Palladacycle / 1,2-dimethoxyethane; water / 2 h / Heating / reflux

9: hydrogenchloride; acetic acid / 3 h

With hydrogenchloride; potassium hydroxide; ethanol; potassium tert-butylate; bromine; sodium acetate; potassium carbonate; acetic acid; triethylamine; triphenylphosphine; zinc; diethylazodicarboxylate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; Palladacycle; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; water; toluene;