endo-3-benzoyloxy-8-aza-bicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester

Base Information

• Chemical Name: endo-3-benzoyloxy-8-aza-bicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester
• CAS No.: 936701-56-3
• Molecular Formula: C₁₉H₂₅NO₄
• Molecular Weight: 331.412
• Mol file: 936701-56-3.mol

Synonyms:endo-3-benzoyloxy-8-aza-bicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester

Chemical Property of endo-3-benzoyloxy-8-aza-bicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of endo-3-benzoyloxy-8-aza-bicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester

There total 6 articles about endo-3-benzoyloxy-8-aza-bicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

di-tert-butyl dicarbonate (24424-99-5) + 3β-benzoyloxy-8-azabicyclo[3.2.1]octane (18470-33-2,20811-95-4,123202-90-4) → endo-3-benzoyloxy-8-aza-bicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester (936701-56-3)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 20 ℃; for 1.5h;

Reference yield:

benzoyl chloride (98-88-4) → endo-3-benzoyloxy-8-aza-bicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester (936701-56-3)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium tert-butylate / tetrahydrofuran / 2 h / 20 °C

2: toluene / 16 h / 20 - 100 °C

3: zinc; acetic acid / 3 h

4: triethylamine / tetrahydrofuran / 1.5 h / 20 °C

With potassium tert-butylate; acetic acid; triethylamine; zinc; In tetrahydrofuran; toluene;

Reference yield:

endo-benzoic acid 8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl ester (19145-60-9) → endo-3-benzoyloxy-8-aza-bicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester (936701-56-3)

Guidance literature:

Multi-step reaction with 3 steps

1: toluene / 16 h / 20 - 100 °C

2: zinc; acetic acid / 3 h

3: triethylamine / tetrahydrofuran / 1.5 h / 20 °C

With acetic acid; triethylamine; zinc; In tetrahydrofuran; toluene;

upstream raw materials:

di-tert-butyl dicarbonate

3β-benzoyloxy-8-azabicyclo[3.2.1]octane

benzoyl chloride

3-tropanol

Downstream raw materials:

Potassium benzoate

(1R,3S,5S)-tert-butyl 3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate

exo-7-[(1S,3S,5R)-(8-aza-bicyclo[3.2.1]oct-3-yl)oxy]-3-phenyl-chromen-2-one hydrochloride