[(R)-(3,5-dichloro-4-methoxyphenyl)-(S)-(2-hydroxy-1-phenylethylamino)]acetic acid methyl ester

Base Information

• Chemical Name: [(R)-(3,5-dichloro-4-methoxyphenyl)-(S)-(2-hydroxy-1-phenylethylamino)]acetic acid methyl ester
• CAS No.: 193073-53-9
• Molecular Formula: C₁₈H₁₉Cl₂NO₄
• Molecular Weight: 384.259
• Mol file: 193073-53-9.mol

Synonyms:[(R)-(3,5-dichloro-4-methoxyphenyl)-(S)-(2-hydroxy-1-phenylethylamino)]acetic acid methyl ester

Chemical Property of [(R)-(3,5-dichloro-4-methoxyphenyl)-(S)-(2-hydroxy-1-phenylethylamino)]acetic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [(R)-(3,5-dichloro-4-methoxyphenyl)-(S)-(2-hydroxy-1-phenylethylamino)]acetic acid methyl ester

There total 1 articles about [(R)-(3,5-dichloro-4-methoxyphenyl)-(S)-(2-hydroxy-1-phenylethylamino)]acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

methanol (67-56-1) + [(R)-(3,5-dichloro-4-methoxyphenyl)-(S)-(2-hydroxy-1-phenylethylamino)]acetonitrile (249757-10-6) → [(S)-(3,5-dichloro-4-methoxyphenyl)-(S)-(2-hydroxy-1-phenylethylamino)]acetic acid methyl ester (193073-55-1) + [(R)-(3,5-dichloro-4-methoxyphenyl)-(S)-(2-hydroxy-1-phenylethylamino)]acetic acid methyl ester (193073-53-9)

Guidance literature:

With hydrogenchloride; at 20 ℃; for 15h;

DOI:10.3987/COM-99-8514

Reference yield: 82.0%

[(R)-(3,5-dichloro-4-methoxyphenyl)-(S)-(2-hydroxy-1-phenylethylamino)]acetic acid methyl ester (193073-53-9) → (R)-Amino-(3,5-dichloro-4-methoxy-phenyl)-acetic acid methyl ester (193073-58-4)

Guidance literature:

With lead(IV) acetate; methanol; In dichloromethane; at 0 ℃;

DOI:10.1016/S0040-4039(97)00938-6

Reference yield: 82.0%

[(R)-(3,5-dichloro-4-methoxyphenyl)-(S)-(2-hydroxy-1-phenylethylamino)]acetic acid methyl ester (193073-53-9) → (R)-(3,5-dichloro-4-methoxy)phenylglycine methyl ester hydrochloride

Guidance literature:

[(R)-(3,5-dichloro-4-methoxyphenyl)-(S)-(2-hydroxy-1-phenylethylamino)]acetic acid methyl ester; With lead(IV) acetate; phosphate buffer; In methanol; dichloromethane; at 0 ℃; for 0.5h; pH=7;

With hydrogenchloride; In diethyl ether; at 20 ℃; for 3h;

DOI:10.3987/COM-99-8514

upstream raw materials:

methanol

[(R)-(3,5-dichloro-4-methoxyphenyl)-(S)-(2-hydroxy-1-phenylethylamino)]acetonitrile

Downstream raw materials:

(R)-Amino-(3,5-dichloro-4-methoxy-phenyl)-acetic acid methyl ester

[2-{(R)-[tert-butoxycarbonylamino-(3,5-dichloro-4-methoxyphenyl)acetyl]methylamino}-(3S)-3-(4-fluoro-3-nitrophenyl)propionylamino]-(R)-(4-methoxyphenyl)acetic acid methyl ester

N-(tert-butoxycarbonyl)-(R)-(3,5-dichloro-4-methoxy)phenylglycine

methyl (R)-2-((tert-butoxycarbonyl)amino)-2-(3,5-dichloro-4-methoxyphenyl)acetate