Acetic acid [1-((1R,3S,5S)-8-benzyl-8-aza-bicyclo[3.2.1]oct-3-ylamino)-eth-(Z)-ylidene]-hydrazide

Base Information

• Chemical Name: Acetic acid [1-((1R,3S,5S)-8-benzyl-8-aza-bicyclo[3.2.1]oct-3-ylamino)-eth-(Z)-ylidene]-hydrazide
• CAS No.: 858651-24-8
• Molecular Formula: C₁₈H₂₆N₄O
• Molecular Weight: 314.431
• Mol file: 858651-24-8.mol

Synonyms:Acetic acid [1-((1R,3S,5S)-8-benzyl-8-aza-bicyclo[3.2.1]oct-3-ylamino)-eth-(Z)-ylidene]-hydrazide

Chemical Property of Acetic acid [1-((1R,3S,5S)-8-benzyl-8-aza-bicyclo[3.2.1]oct-3-ylamino)-eth-(Z)-ylidene]-hydrazide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Acetic acid [1-((1R,3S,5S)-8-benzyl-8-aza-bicyclo[3.2.1]oct-3-ylamino)-eth-(Z)-ylidene]-hydrazide

There total 2 articles about Acetic acid [1-((1R,3S,5S)-8-benzyl-8-aza-bicyclo[3.2.1]oct-3-ylamino)-eth-(Z)-ylidene]-hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-((1R,3S,5S)-8-Benzyl-8-aza-bicyclo[3.2.1]oct-3-yl)-acetamide (84923-28-4) → Acetic acid [1-((1R,3S,5S)-8-benzyl-8-aza-bicyclo[3.2.1]oct-3-ylamino)-eth-(Z)-ylidene]-hydrazide (858651-24-8)

Guidance literature:

Multi-step reaction with 2 steps

1: POCl₃; pyridine / CHCl₃ / 20 °C

2: CHCl₃ / Heating

With pyridine; trichlorophosphate; In chloroform;

DOI:10.1055/s-2005-865208

Reference yield:

N-((1R,3S,5S)-8-Benzyl-8-aza-bicyclo[3.2.1]oct-3-yl)-acetimidoyl chloride + acetic acid hydrazide (1068-57-1) → Acetic acid [1-((1R,3S,5S)-8-benzyl-8-aza-bicyclo[3.2.1]oct-3-ylamino)-eth-(Z)-ylidene]-hydrazide (858651-24-8)

Guidance literature:

In chloroform; Heating;

DOI:10.1055/s-2005-865208

Reference yield: 59.0%

Acetic acid [1-((1R,3S,5S)-8-benzyl-8-aza-bicyclo[3.2.1]oct-3-ylamino)-eth-(Z)-ylidene]-hydrazide (858651-24-8) → (1S,3S,5R)-8-Benzyl-3-(3,5-dimethyl-[1,2,4]triazol-4-yl)-8-aza-bicyclo[3.2.1]octane

Guidance literature:

With toluene-4-sulfonic acid; In toluene; Heating;

DOI:10.1055/s-2005-865208

upstream raw materials:

acetic acid hydrazide

N-((1R,3S,5S)-8-Benzyl-8-aza-bicyclo[3.2.1]oct-3-yl)-acetamide