diethyl 2-((1R,2S)-3-oxo-2-(2,2,6,6-tetramethylpiperidin-1-yloxy)-1-p-tolylpropyl)malonate

Base Information

Chemical Name:diethyl 2-((1R,2S)-3-oxo-2-(2,2,6,6-tetramethylpiperidin-1-yloxy)-1-p-tolylpropyl)malonate
CAS No.:1381851-38-2
Molecular Formula:C₂₆H₃₉NO₆
Molecular Weight:461.599
Hs Code.:

Synonyms:diethyl 2-((1R,2S)-3-oxo-2-(2,2,6,6-tetramethylpiperidin-1-yloxy)-1-p-tolylpropyl)malonate

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Chemical Property of diethyl 2-((1R,2S)-3-oxo-2-(2,2,6,6-tetramethylpiperidin-1-yloxy)-1-p-tolylpropyl)malonate

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Technology Process of diethyl 2-((1R,2S)-3-oxo-2-(2,2,6,6-tetramethylpiperidin-1-yloxy)-1-p-tolylpropyl)malonate

There total 1 articles about diethyl 2-((1R,2S)-3-oxo-2-(2,2,6,6-tetramethylpiperidin-1-yloxy)-1-p-tolylpropyl)malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 2564-83-2,45842-10-2,126517-51-9,25657-03-8,26933-82-4,54637-06-8,64104-42-3
2,2,6,6-Tetramethyl-1-piperidinyloxy free radical

: 1504-75-2
3-(4-methylphenyl)acrylaldehyde

: 105-53-3
diethyl malonate

: 1381851-38-2
diethyl 2-((1R,2S)-3-oxo-2-(2,2,6,6-tetramethylpiperidin-1-yloxy)-1-p-tolylpropyl)malonate

Guidance literature:: With (2S)-2-{diphenyl[(trimethylsilyl)oxy]methyl}pyrrolidine; 1-Adamantanecarboxylic acid; oxygen; copper(II) bis(trifluoromethanesulfonate); In acetonitrile; for 24h; under 760.051 Torr; stereoselective reaction; Green chemistry;
DOI:10.1002/ejoc.201300333

Reference yield: 79.0%

: 1381851-38-2
diethyl 2-((1R,2S)-3-oxo-2-(2,2,6,6-tetramethylpiperidin-1-yloxy)-1-p-tolylpropyl)malonate

: 100-46-9
benzylamine

: (3S,4R,5S)-ethyl 1-benzyl-2-oxo-5-(2,2,6,6-tetramethylpiperidin-1-yloxy)-4-p-tolylpiperidine-3-carboxylate

Guidance literature:: With sodium cyanoborohydride; acetic acid; In 1,4-dioxane; at 0 - 40 ℃;
DOI:10.1016/j.bmcl.2016.04.092

Reference yield:

: 1381851-38-2
diethyl 2-((1R,2S)-3-oxo-2-(2,2,6,6-tetramethylpiperidin-1-yloxy)-1-p-tolylpropyl)malonate

: ((3S,4R,5S)-1-benzyl-5-(2,2,6,6-tetramethylpiperidin-1-yloxy)-4-p-tolylpiperidin-3-yl)methanol

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid; sodium cyanoborohydride / 1,4-dioxane / 0 - 40 °C

2: lithium aluminium tetrahydride / tetrahydrofuran / -78 - 65 °C

With lithium aluminium tetrahydride; sodium cyanoborohydride; acetic acid; In tetrahydrofuran; 1,4-dioxane;
DOI:10.1016/j.bmcl.2016.04.092