2-[2-bromo-4-(cyclopropylmethoxy)phenyl]-1-(5-{[tris(1-methylethyl)silyl]oxy}pyridin-2-yl)ethanol

Base Information

Chemical Name:2-[2-bromo-4-(cyclopropylmethoxy)phenyl]-1-(5-{[tris(1-methylethyl)silyl]oxy}pyridin-2-yl)ethanol
CAS No.:1380068-76-7
Molecular Formula:C₂₆H₃₈BrNO₃Si
Molecular Weight:520.582
Hs Code.:

Synonyms:2-[2-bromo-4-(cyclopropylmethoxy)phenyl]-1-(5-{[tris(1-methylethyl)silyl]oxy}pyridin-2-yl)ethanol

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Chemical Property of 2-[2-bromo-4-(cyclopropylmethoxy)phenyl]-1-(5-{[tris(1-methylethyl)silyl]oxy}pyridin-2-yl)ethanol

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Technology Process of 2-[2-bromo-4-(cyclopropylmethoxy)phenyl]-1-(5-{[tris(1-methylethyl)silyl]oxy}pyridin-2-yl)ethanol

There total 4 articles about 2-[2-bromo-4-(cyclopropylmethoxy)phenyl]-1-(5-{[tris(1-methylethyl)silyl]oxy}pyridin-2-yl)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1380068-75-6
2-[2-bromo-4-(cyclopropylmethoxy)phenyl]-1-(5-{[tris(1-methylethyl)silyl]oxy}pyridin-2-yl)ethanone

: 1380068-76-7
2-[2-bromo-4-(cyclopropylmethoxy)phenyl]-1-(5-{[tris(1-methylethyl)silyl]oxy}pyridin-2-yl)ethanol

Guidance literature:: With sodium tetrahydroborate; ethanol; at 20 ℃; for 1h;

Reference yield:

: 1380068-72-3
cyclopropylmethyl [2-bromo-4-(cyclopropylmethoxy)phenyl]acetate

: 1380068-76-7
2-[2-bromo-4-(cyclopropylmethoxy)phenyl]-1-(5-{[tris(1-methylethyl)silyl]oxy}pyridin-2-yl)ethanol

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydroxide; water / methanol / 2 h / 50 °C

2.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / acetonitrile / 15 h / 20 °C

3.1: n-butyllithium / hexane; diethyl ether / 1.25 h / -78 - 0 °C

3.2: 15 h / -78 - 20 °C

4.1: ethanol; sodium tetrahydroborate / 1 h / 20 °C

With sodium tetrahydroborate; n-butyllithium; ethanol; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In methanol; diethyl ether; hexane; acetonitrile;

Reference yield:

: 66916-99-2
2-(2-bromo-4-(methoxy)phenyl)acetic acid

: 1380068-76-7
2-[2-bromo-4-(cyclopropylmethoxy)phenyl]-1-(5-{[tris(1-methylethyl)silyl]oxy}pyridin-2-yl)ethanol

Guidance literature:: Multi-step reaction with 6 steps

1.1: boron tribromide / dichloromethane / 3 h / Reflux

1.2: Cooling with ice

2.1: potassium carbonate / N,N-dimethyl-formamide / 8 h / 80 °C

3.1: sodium hydroxide; water / methanol / 2 h / 50 °C

4.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / acetonitrile / 15 h / 20 °C

5.1: n-butyllithium / hexane; diethyl ether / 1.25 h / -78 - 0 °C

5.2: 15 h / -78 - 20 °C

6.1: ethanol; sodium tetrahydroborate / 1 h / 20 °C

With sodium tetrahydroborate; n-butyllithium; ethanol; water; boron tribromide; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In methanol; diethyl ether; hexane; dichloromethane; N,N-dimethyl-formamide; acetonitrile;