cyclopropylmethyl [2-bromo-4-(cyclopropylmethoxy)phenyl]acetate

Base Information

• Chemical Name: cyclopropylmethyl [2-bromo-4-(cyclopropylmethoxy)phenyl]acetate
• CAS No.: 1380068-72-3
• Molecular Formula: C₁₆H₁₉BrO₃
• Molecular Weight: 339.229
• Mol file: 1380068-72-3.mol

Synonyms:cyclopropylmethyl [2-bromo-4-(cyclopropylmethoxy)phenyl]acetate

Chemical Property of cyclopropylmethyl [2-bromo-4-(cyclopropylmethoxy)phenyl]acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of cyclopropylmethyl [2-bromo-4-(cyclopropylmethoxy)phenyl]acetate

There total 1 articles about cyclopropylmethyl [2-bromo-4-(cyclopropylmethoxy)phenyl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(2-bromo-4-hydroxyphenyl)acetic acid (88491-44-5) + cyclopropylcarbinyl bromide (7051-34-5) → cyclopropylmethyl [2-bromo-4-(cyclopropylmethoxy)phenyl]acetate (1380068-72-3)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 8h;

Reference yield:

cyclopropylmethyl [2-bromo-4-(cyclopropylmethoxy)phenyl]acetate (1380068-72-3) → [2-bromo-4-(cyclopropylmethoxy)phenyl]acetic acid (1380068-73-4)

Guidance literature:

cyclopropylmethyl [2-bromo-4-(cyclopropylmethoxy)phenyl]acetate; With water; sodium hydroxide; In methanol; at 50 ℃; for 2h;

With hydrogenchloride; In water;

Reference yield:

cyclopropylmethyl [2-bromo-4-(cyclopropylmethoxy)phenyl]acetate (1380068-72-3) → 2-[2-bromo-4-(cyclopropylmethoxy)phenyl]-N-methoxy-N-methylacetamide (1380068-74-5)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide; water / methanol / 2 h / 50 °C

2: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / acetonitrile / 15 h / 20 °C

With water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In methanol; acetonitrile;

upstream raw materials:

2-(2-bromo-4-hydroxyphenyl)acetic acid

cyclopropylcarbinyl bromide

Downstream raw materials:

[2-bromo-4-(cyclopropylmethoxy)phenyl]acetic acid

2-[2-bromo-4-(cyclopropylmethoxy)phenyl]-N-methoxy-N-methylacetamide

2-[2-bromo-4-(cyclopropylmethoxy)phenyl]-1-(5-{[tris(1-methylethyl)silyl]oxy}pyridin-2-yl)ethanone

2-[2-bromo-4-(cyclopropylmethoxy)phenyl]-1-(5-{[tris(1-methylethyl)silyl]oxy}pyridin-2-yl)ethanol