N-(N-TRIFLUOROACETYL-L-G-GLUTAMYL)-L-CYSTEINE DIMETHYL ESTER

Base Information

Chemical Name:N-(N-TRIFLUOROACETYL-L-G-GLUTAMYL)-L-CYSTEINE DIMETHYL ESTER
CAS No.:83851-50-7
Molecular Formula:C12H17F3N2O6S
Molecular Weight:374.33
Hs Code.:
Mol file:83851-50-7.mol

Synonyms:N-(N-TRIFLUOROACETYL-L-GAMMA-GLUTAMYL)-L-CYSTEINE DIMETHYL ESTER;N-(N-TRIFLUOROACETYL-L-G-GLUTAMYL)-L-CYSTEINE DIMETHYL ESTER

Suppliers and Price of N-(N-TRIFLUOROACETYL-L-G-GLUTAMYL)-L-CYSTEINE DIMETHYL ESTER

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 5 raw suppliers

Chemical Property of N-(N-TRIFLUOROACETYL-L-G-GLUTAMYL)-L-CYSTEINE DIMETHYL ESTER

Chemical Property:

Vapor Pressure:6.99E-11mmHg at 25°C
Melting Point:124-125
Refractive Index:1.466
Boiling Point:519.2°C at 760 mmHg
Flash Point:267.8°C
PSA：149.60000
Density:1.353g/cm³
LogP:0.35610

Purity/Quality:: 98%min ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:Xi

MSDS Files:: SDS file from LookChem

Useful:

Uses N-[N-(Trifluoroacetyl)-L-γ-glutamyl]-L-cysteine Dimethyl Ester is an intermediate in the synthesis of leukotriene analogs.

Technology Process of N-(N-TRIFLUOROACETYL-L-G-GLUTAMYL)-L-CYSTEINE DIMETHYL ESTER

There total 5 articles about N-(N-TRIFLUOROACETYL-L-G-GLUTAMYL)-L-CYSTEINE DIMETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 84344-30-9
(S)-4-((R)-1-Methoxycarbonyl-2-{(R)-2-methoxycarbonyl-2-[(S)-4-methoxycarbonyl-4-(2,2,2-trifluoro-acetylamino)-butyrylamino]-ethyldisulfanyl}-ethylcarbamoyl)-2-(2,2,2-trifluoro-acetylamino)-butyric acid methyl ester

: 83851-50-7
(S)-4-((R)-2-Mercapto-1-methoxycarbonyl-ethylcarbamoyl)-2-(2,2,2-trifluoro-acetylamino)-butyric acid methyl ester

Guidance literature:: With acetic acid; zinc; In ethyl acetate;
DOI:10.1016/S0040-4039(00)88671-2

Reference yield:

: 56-86-0,21675-62-7,23009-64-5,25104-13-6,84960-48-5,25513-46-6
L-glutamic acid

: 83851-50-7
(S)-4-((R)-2-Mercapto-1-methoxycarbonyl-ethylcarbamoyl)-2-(2,2,2-trifluoro-acetylamino)-butyric acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 55 percent

2: 0.03 h / Heating

3: thionyl chloride / diethyl ether; dimethylformamide / 2 h / 23 °C

4: 1.) triethylamine / 1.) THF, 23 deg C, 15 h

5: 73 percent / zinc/acetic acid / ethyl acetate

With thionyl chloride; acetic acid; triethylamine; zinc; In diethyl ether; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)88671-2

Reference yield:

: 1535-57-5
(S)-N-(2,6-dioxotetrahydro-2H-pyran-3-yl)-2,2,2-trifluoroacetamide

: 83851-50-7
(S)-4-((R)-2-Mercapto-1-methoxycarbonyl-ethylcarbamoyl)-2-(2,2,2-trifluoro-acetylamino)-butyric acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 0.03 h / Heating

2: thionyl chloride / diethyl ether; dimethylformamide / 2 h / 23 °C

3: 1.) triethylamine / 1.) THF, 23 deg C, 15 h

4: 73 percent / zinc/acetic acid / ethyl acetate

With thionyl chloride; acetic acid; triethylamine; zinc; In diethyl ether; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)88671-2