N-(2-(tert-butylamino)-2-oxo-1-phenylethyl)-N-(prop-2-yn-1-yl)benzamide

Base Information

• Chemical Name: N-(2-(tert-butylamino)-2-oxo-1-phenylethyl)-N-(prop-2-yn-1-yl)benzamide
• CAS No.: 1404471-72-2
• Molecular Formula: C₂₂H₂₄N₂O₂
• Molecular Weight: 348.445
• Mol file: 1404471-72-2.mol

Synonyms:N-(2-(tert-butylamino)-2-oxo-1-phenylethyl)-N-(prop-2-yn-1-yl)benzamide

Chemical Property of N-(2-(tert-butylamino)-2-oxo-1-phenylethyl)-N-(prop-2-yn-1-yl)benzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2-(tert-butylamino)-2-oxo-1-phenylethyl)-N-(prop-2-yn-1-yl)benzamide

There total 2 articles about N-(2-(tert-butylamino)-2-oxo-1-phenylethyl)-N-(prop-2-yn-1-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

tert-butyl isocyanide + benzaldehyde (100-52-7) + benzoic acid (65-85-0,8013-63-6) + Propargylamine (2450-71-7) → N-(2-(tert-butylamino)-2-oxo-1-phenylethyl)-N-(prop-2-yn-1-yl)benzamide (1404471-72-2)

Guidance literature:

With indium(III) chloride; In methanol; at 50 ℃; for 2h; Microwave irradiation;

DOI:10.1021/ol3024727

Reference yield: 86.0%

tert-butylisonitrile (119072-55-8,7188-38-7) + benzaldehyde (100-52-7) + benzoic acid (65-85-0,8013-63-6) + Propargylamine (2450-71-7) → N-(2-(tert-butylamino)-2-oxo-1-phenylethyl)-N-(prop-2-yn-1-yl)benzamide (1404471-72-2)

Guidance literature:

benzaldehyde; Propargylamine; In ethanol; at 20 ℃; for 1h;

benzoic acid; In ethanol; at 20 ℃; for 0.25h;

tert-butylisonitrile; In ethanol; at 20 ℃; for 24h;

DOI:10.1039/c9ob01963d

Reference yield: 84.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + N-(2-(tert-butylamino)-2-oxo-1-phenylethyl)-N-(prop-2-yn-1-yl)benzamide (1404471-72-2) → N-(buta-2,3-dien-1-yl)-N-(2-(tert-butylamino)-2-oxo-1-phenylethyl)benzamide

Guidance literature:

With copper(I) bromide; In 1,4-dioxane; at 100 ℃; for 12h; Reagent/catalyst; Solvent; Catalytic behavior; Inert atmosphere;

DOI:10.1039/c9ob01963d

upstream raw materials:

benzaldehyde

benzoic acid

Propargylamine

tert-butylisonitrile

Downstream raw materials:

1-benzoyl-N-tert-butyl-2-phenyl-2,3-dihydro-1H-pyrrole-2-carboxamide