(+/-)-(E)-3-[1'-benzyl-4-oxo-spiro(chromane-2,3'-pyrrolidine)-6-yl]-N-(tetrahydro-pyran-2-yloxy)-acrylamide

Base Information

Chemical Name:(+/-)-(E)-3-[1'-benzyl-4-oxo-spiro(chromane-2,3'-pyrrolidine)-6-yl]-N-(tetrahydro-pyran-2-yloxy)-acrylamide
CAS No.:1291076-57-7
Molecular Formula:C₂₇H₃₀N₂O₅
Molecular Weight:462.546
Hs Code.:

Synonyms:(+/-)-(E)-3-[1'-benzyl-4-oxo-spiro(chromane-2,3'-pyrrolidine)-6-yl]-N-(tetrahydro-pyran-2-yloxy)-acrylamide

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Chemical Property of (+/-)-(E)-3-[1'-benzyl-4-oxo-spiro(chromane-2,3'-pyrrolidine)-6-yl]-N-(tetrahydro-pyran-2-yloxy)-acrylamide

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Technology Process of (+/-)-(E)-3-[1'-benzyl-4-oxo-spiro(chromane-2,3'-pyrrolidine)-6-yl]-N-(tetrahydro-pyran-2-yloxy)-acrylamide

There total 2 articles about (+/-)-(E)-3-[1'-benzyl-4-oxo-spiro(chromane-2,3'-pyrrolidine)-6-yl]-N-(tetrahydro-pyran-2-yloxy)-acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1291076-57-7
(+/-)-(E)-3-[1'-benzyl-4-oxo-spiro(chromane-2,3'-pyrrolidine)-6-yl]-N-(tetrahydro-pyran-2-yloxy)-acrylamide

Guidance literature:

Reference yield: 43.0%

: 6723-30-4
O-2-tetrahydro-2H-pyranhydroxylamine

: 1291076-56-6
(±)-(E)-3-[1'-benzyl-4-oxospiro(chromane-2,3'-pyrrolidine)-6-yl]acrylic acid hydrochloride

: 1291076-57-7
(+/-)-(E)-3-[1'-benzyl-4-oxo-spiro(chromane-2,3'-pyrrolidine)-6-yl]-N-(tetrahydro-pyran-2-yloxy)-acrylamide

Guidance literature:: (±)-(E)-3-[1'-benzyl-4-oxospiro(chromane-2,3'-pyrrolidine)-6-yl]acrylic acid hydrochloride; With triethylamine; In dichloromethane; at 0 ℃;

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; for 3h;

O-2-tetrahydro-2H-pyranhydroxylamine; In dichloromethane; at 20 ℃;
DOI:10.1016/j.ejmech.2015.11.010