(±)-(E)-3-[1'-benzyl-4-oxospiro(chromane-2,3'-pyrrolidine)-6-yl]acrylic acid hydrochloride

Base Information

Chemical Name:(±)-(E)-3-[1'-benzyl-4-oxospiro(chromane-2,3'-pyrrolidine)-6-yl]acrylic acid hydrochloride
CAS No.:1291076-56-6
Molecular Formula:C₂₂H₂₁NO₄*ClH
Molecular Weight:399.874
Hs Code.:

Synonyms:(±)-(E)-3-[1'-benzyl-4-oxospiro(chromane-2,3'-pyrrolidine)-6-yl]acrylic acid hydrochloride

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (±)-(E)-3-[1'-benzyl-4-oxospiro(chromane-2,3'-pyrrolidine)-6-yl]acrylic acid hydrochloride

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Technology Process of (±)-(E)-3-[1'-benzyl-4-oxospiro(chromane-2,3'-pyrrolidine)-6-yl]acrylic acid hydrochloride

There total 2 articles about (±)-(E)-3-[1'-benzyl-4-oxospiro(chromane-2,3'-pyrrolidine)-6-yl]acrylic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1291076-55-5
(±)-(E)-3-[1'-benzyl-4-oxospiro(chromane-2,3'-pyrrolidine)-6-yl]acrylic acid methyl ester

: 1291076-56-6
(±)-(E)-3-[1'-benzyl-4-oxospiro(chromane-2,3'-pyrrolidine)-6-yl]acrylic acid hydrochloride

Guidance literature:: With hydrogenchloride; water; acetic acid; at 85 ℃; for 3h;
DOI:10.1016/j.ejmech.2015.11.010

Reference yield: 90.0%

: 1291076-56-6
(±)-(E)-3-[1'-benzyl-4-oxospiro(chromane-2,3'-pyrrolidine)-6-yl]acrylic acid hydrochloride

Guidance literature:

Reference yield: 43.0%

: 6723-30-4
O-2-tetrahydro-2H-pyranhydroxylamine

: 1291076-56-6
(±)-(E)-3-[1'-benzyl-4-oxospiro(chromane-2,3'-pyrrolidine)-6-yl]acrylic acid hydrochloride

: 1291076-57-7
(+/-)-(E)-3-[1'-benzyl-4-oxo-spiro(chromane-2,3'-pyrrolidine)-6-yl]-N-(tetrahydro-pyran-2-yloxy)-acrylamide

Guidance literature:: (±)-(E)-3-[1'-benzyl-4-oxospiro(chromane-2,3'-pyrrolidine)-6-yl]acrylic acid hydrochloride; With triethylamine; In dichloromethane; at 0 ℃;

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; for 3h;

O-2-tetrahydro-2H-pyranhydroxylamine; In dichloromethane; at 20 ℃;
DOI:10.1016/j.ejmech.2015.11.010