(rac)-8-(cyclohexylmethoxy)-N-(1-hydroxybutan-2-yl)-2-methylimidazo[1,2-a]pyridine-3-carboxamide formate

Base Information

Chemical Name:(rac)-8-(cyclohexylmethoxy)-N-(1-hydroxybutan-2-yl)-2-methylimidazo[1,2-a]pyridine-3-carboxamide formate
CAS No.:1609164-44-4
Molecular Formula:CH₂O₂*C₂₀H₂₉N₃O₃
Molecular Weight:405.494
Hs Code.:

Synonyms:(rac)-8-(cyclohexylmethoxy)-N-(1-hydroxybutan-2-yl)-2-methylimidazo[1,2-a]pyridine-3-carboxamide formate

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Chemical Property of (rac)-8-(cyclohexylmethoxy)-N-(1-hydroxybutan-2-yl)-2-methylimidazo[1,2-a]pyridine-3-carboxamide formate

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Technology Process of (rac)-8-(cyclohexylmethoxy)-N-(1-hydroxybutan-2-yl)-2-methylimidazo[1,2-a]pyridine-3-carboxamide formate

There total 5 articles about (rac)-8-(cyclohexylmethoxy)-N-(1-hydroxybutan-2-yl)-2-methylimidazo[1,2-a]pyridine-3-carboxamide formate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 96-20-8,13054-87-0
2-aminobutanol

: 64-18-6
formic acid

: 1415501-17-5
8-(Cyclohexylmethoxy)-2-methylimidazo[1,2-a] pyridine-3-carboxylic acid

: 1609164-44-4
(rac)-8-(cyclohexylmethoxy)-N-(1-hydroxybutan-2-yl)-2-methylimidazo[1,2-a]pyridine-3-carboxamide formate

Guidance literature:: 2-aminobutanol; 8-(Cyclohexylmethoxy)-2-methylimidazo[1,2-a] pyridine-3-carboxylic acid; With 4-methyl-morpholine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; In dichloromethane; at 20 ℃; Inert atmosphere;

formic acid; In water; acetonitrile;

Reference yield:

: 16867-03-1
2-amino-3-hydroxypyridine

: 1609164-44-4
(rac)-8-(cyclohexylmethoxy)-N-(1-hydroxybutan-2-yl)-2-methylimidazo[1,2-a]pyridine-3-carboxamide formate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydroxide / methanol / 0.17 h / 20 °C

1.2: 16 h / 20 °C

2.1: ethanol / Reflux

3.1: water; sodium hydroxide / 1,4-dioxane / 20 °C

4.1: 4-methyl-morpholine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / dichloromethane / 20 °C / Inert atmosphere

With 4-methyl-morpholine; water; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; sodium hydroxide; In 1,4-dioxane; methanol; ethanol; dichloromethane;

Reference yield:

: ethyl 8-(cyclohexylmethoxy)-2-methylimidazo[1,2-a]pyridine-3-carboxylate

: 1609164-44-4
(rac)-8-(cyclohexylmethoxy)-N-(1-hydroxybutan-2-yl)-2-methylimidazo[1,2-a]pyridine-3-carboxamide formate

Guidance literature:: Multi-step reaction with 2 steps

1: water; sodium hydroxide / 1,4-dioxane / 20 °C

2: 4-methyl-morpholine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / dichloromethane / 20 °C / Inert atmosphere

With 4-methyl-morpholine; water; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; sodium hydroxide; In 1,4-dioxane; dichloromethane;