pivaloyloxymethyl trans-4-aminomethylcyclohexanecarboxylate hydrochloride

Base Information

Chemical Name:pivaloyloxymethyl trans-4-aminomethylcyclohexanecarboxylate hydrochloride
CAS No.:87589-22-8
Molecular Formula:C₁₄H₂₅NO₄*ClH
Molecular Weight:307.818
Hs Code.:

Synonyms:pivaloyloxymethyl trans-4-aminomethylcyclohexanecarboxylate hydrochloride

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Chemical Property of pivaloyloxymethyl trans-4-aminomethylcyclohexanecarboxylate hydrochloride

Chemical Property:

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Technology Process of pivaloyloxymethyl trans-4-aminomethylcyclohexanecarboxylate hydrochloride

There total 5 articles about pivaloyloxymethyl trans-4-aminomethylcyclohexanecarboxylate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: trans-4-(tert-butoxycarbonylamino-methyl)-cyclohexanecarboxylic acid

: 18997-19-8
Chloromethyl pivalate

: 87589-22-8
pivaloyloxymethyl trans-4-aminomethylcyclohexanecarboxylate hydrochloride

Guidance literature:: With hydrogenchloride; sodium bromide; In N-methyl-acetamide; dichloromethane; water; ethyl acetate; triethylamine;

Reference yield:

: 87589-21-7
4-(tert-Butoxycarbonylamino-methyl)-cyclohexanecarboxylic acid 2,2-dimethyl-propionyloxymethyl ester

: 87589-22-8
pivaloyloxymethyl trans-4-aminomethylcyclohexanecarboxylate hydrochloride

Guidance literature:: With hydrogenchloride; In ethyl acetate; at 0 ℃; for 3h; Yield given;
DOI:10.1021/jm00154a004

Reference yield:

: 18997-19-8
Chloromethyl pivalate

: 87589-22-8
pivaloyloxymethyl trans-4-aminomethylcyclohexanecarboxylate hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) tetrabutylammonium hydrogen sulfate (QHSO₄), 2 M aq. NaOH / 2.) trichloroethylene, reflux, 3 h

2: HCl(g) / ethyl acetate / 3 h / 0 °C

With hydrogenchloride; sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate; In ethyl acetate;
DOI:10.1021/jm00154a004