N-(3-BzlO-4-Me-2-nitrobenzoyl)-O-(Boc-MeVal)Thr-D-Thr-(OBzl)-Pro-Sar-OtBu

Base Information

Chemical Name:N-(3-BzlO-4-Me-2-nitrobenzoyl)-O-(Boc-MeVal)Thr-D-Thr-(OBzl)-Pro-Sar-OtBu
CAS No.:131545-60-3
Molecular Formula:C₅₃H₇₂N₆O₁₄
Molecular Weight:1017.19
Hs Code.:

Synonyms:N-(3-BzlO-4-Me-2-nitrobenzoyl)-O-(Boc-MeVal)Thr-D-Thr-(OBzl)-Pro-Sar-OtBu

Suppliers and Price of N-(3-BzlO-4-Me-2-nitrobenzoyl)-O-(Boc-MeVal)Thr-D-Thr-(OBzl)-Pro-Sar-OtBu

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-(3-BzlO-4-Me-2-nitrobenzoyl)-O-(Boc-MeVal)Thr-D-Thr-(OBzl)-Pro-Sar-OtBu

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-(3-BzlO-4-Me-2-nitrobenzoyl)-O-(Boc-MeVal)Thr-D-Thr-(OBzl)-Pro-Sar-OtBu

There total 6 articles about N-(3-BzlO-4-Me-2-nitrobenzoyl)-O-(Boc-MeVal)Thr-D-Thr-(OBzl)-Pro-Sar-OtBu which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 45170-31-8
Boc-N-Me-Val-OH

: 131545-59-0
(3-BzlO-4-Me-2-nitrobenzoyl)-Thr-D-Thr(OBzl)-Pro-Sar-OtBu

: 131545-60-3
N-(3-BzlO-4-Me-2-nitrobenzoyl)-O-(Boc-MeVal)Thr-D-Thr-(OBzl)-Pro-Sar-OtBu

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 22 ℃; for 18h;
DOI:10.1021/jm00108a009

Reference yield:

: 5616-82-0
N-(benzyloxycarbonyl)prolylsarcosine tert-butyl ester

: 131545-60-3
N-(3-BzlO-4-Me-2-nitrobenzoyl)-O-(Boc-MeVal)Thr-D-Thr-(OBzl)-Pro-Sar-OtBu

Guidance literature:: Multi-step reaction with 5 steps

1: H₂ / Pd/C / ethanol / 16 h

2: dicyclohexylcarbodiimide (DCC) / CH₂Cl₂ / 18 h / 22 °C

3: Et₂NH / CH₂Cl₂ / 5 h

4: N-hydroxy-5-norbornene-2,3-dicarboximide (HONB), dicyclohexylcarbodiimide (DCC) / 18 h / 22 °C

5: 71 percent / 4-(dimethylamino)pyridine (DMAP), dicyclohexylcarbodiimide (DCC) / CH₂Cl₂ / 18 h / 22 °C

With dmap; N-hydroxy-5-norbornene-2,3-dicarboximide; hydrogen; diethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In ethanol; dichloromethane;
DOI:10.1021/jm00108a009

Reference yield:

: 2441-62-5
<3-(benzyloxy)-4-methyl-2-nitro-benzoyl>-L-threonine

: 131545-60-3
N-(3-BzlO-4-Me-2-nitrobenzoyl)-O-(Boc-MeVal)Thr-D-Thr-(OBzl)-Pro-Sar-OtBu

Guidance literature:: Multi-step reaction with 2 steps

1: N-hydroxy-5-norbornene-2,3-dicarboximide (HONB), dicyclohexylcarbodiimide (DCC) / 18 h / 22 °C

2: 71 percent / 4-(dimethylamino)pyridine (DMAP), dicyclohexylcarbodiimide (DCC) / CH₂Cl₂ / 18 h / 22 °C

With dmap; N-hydroxy-5-norbornene-2,3-dicarboximide; dicyclohexyl-carbodiimide; In dichloromethane;
DOI:10.1021/jm00108a009