2,2-Dimethyl-N,N'-bis-((1R,2R)-2-{[1-phenyl-meth-(E)-ylidene]-amino}-cyclohexyl)-malonamide

Base Information

Chemical Name:2,2-Dimethyl-N,N'-bis-((1R,2R)-2-{[1-phenyl-meth-(E)-ylidene]-amino}-cyclohexyl)-malonamide
CAS No.:323187-52-6
Molecular Formula:C₃₁H₄₀N₄O₂
Molecular Weight:500.684
Hs Code.:

Synonyms:2,2-Dimethyl-N,N'-bis-((1R,2R)-2-{[1-phenyl-meth-(E)-ylidene]-amino}-cyclohexyl)-malonamide

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Chemical Property of 2,2-Dimethyl-N,N'-bis-((1R,2R)-2-{[1-phenyl-meth-(E)-ylidene]-amino}-cyclohexyl)-malonamide

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Technology Process of 2,2-Dimethyl-N,N'-bis-((1R,2R)-2-{[1-phenyl-meth-(E)-ylidene]-amino}-cyclohexyl)-malonamide

There total 4 articles about 2,2-Dimethyl-N,N'-bis-((1R,2R)-2-{[1-phenyl-meth-(E)-ylidene]-amino}-cyclohexyl)-malonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 100-52-7
benzaldehyde

: 323187-56-0
N¹,N³-bis((1R,2R)-2-aminocyclohexyl)-2,2-dimethylmalonamide

: 323187-52-6
2,2-Dimethyl-N,N'-bis-((1R,2R)-2-{[1-phenyl-meth-(E)-ylidene]-amino}-cyclohexyl)-malonamide

Guidance literature:: In ethanol; for 16h; Heating;
DOI:10.1016/S0040-4039(00)01621-X

Reference yield:

: 20439-47-8
(1R,2R)-1,2-diaminocyclohexane

: 323187-52-6
2,2-Dimethyl-N,N'-bis-((1R,2R)-2-{[1-phenyl-meth-(E)-ylidene]-amino}-cyclohexyl)-malonamide

Guidance literature:: Multi-step reaction with 4 steps

1: 74 percent / ethanol / 16 h / 20 °C

2: 75 percent / Et₃N / CH₂Cl₂ / 16 h / 0 °C

3: TFA / CH₂Cl₂ / 2 h / 20 °C

4: 98 percent / ethanol / 16 h / Heating

With triethylamine; trifluoroacetic acid; In ethanol; dichloromethane;
DOI:10.1016/S0040-4039(00)01621-X

Reference yield:

: 146504-07-6
tert-butyl ((1R,2R)-2-aminocyclohexyl)carbamate

: 323187-52-6
2,2-Dimethyl-N,N'-bis-((1R,2R)-2-{[1-phenyl-meth-(E)-ylidene]-amino}-cyclohexyl)-malonamide

Guidance literature:: Multi-step reaction with 3 steps

1: 75 percent / Et₃N / CH₂Cl₂ / 16 h / 0 °C

2: TFA / CH₂Cl₂ / 2 h / 20 °C

3: 98 percent / ethanol / 16 h / Heating

With triethylamine; trifluoroacetic acid; In ethanol; dichloromethane;
DOI:10.1016/S0040-4039(00)01621-X