1,3-DICHLOROACETONE METHOXYCARBONYLHYDRAZONE

Base Information

• Chemical Name: 1,3-DICHLOROACETONE METHOXYCARBONYLHYDRAZONE
• CAS No.: 87595-89-9
• Molecular Formula: C5H8 Cl2 N2 O2
• Molecular Weight: 199.04
• Hs Code.: 2928000090
• Mol file: 87595-89-9.mol

Synonyms:Hydrazinecarboxylicacid, [2-chloro-1-(chloromethyl)ethylidene]-, methyl ester (9CI)

Chemical Property of 1,3-DICHLOROACETONE METHOXYCARBONYLHYDRAZONE

Chemical Property:

• PSA: 50.69000
• LogP: 1.56690

Purity/Quality:

99%min ^*data from raw suppliers

1,3-DICHLOROACETONE METHOXYCARBONYLHYDRAZONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,3-DICHLOROACETONE METHOXYCARBONYLHYDRAZONE

There total 1 articles about 1,3-DICHLOROACETONE METHOXYCARBONYLHYDRAZONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

hydrazinecarboxylic acid methyl ester (6294-89-9) + 1,3-Dichloroacetone (534-07-6) → methyl 2-[2-chloro-1-(chloromethyl)ethylidene]-1-hydrazinecarboxylate (87595-89-9)

Guidance literature:

In diethyl ether; for 15h; Ambient temperature;

Reference yield:

methyl 2-[2-chloro-1-(chloromethyl)ethylidene]-1-hydrazinecarboxylate (87595-89-9) → [3-[Benzyl-(4-fluoro-phenyl)-amino]-2-(methoxycarbonyl-hydrazono)-propyl]-phosphonic acid diethyl ester (119592-15-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / toluene / 2 h / Heating

2: Et₃N / tetrahydrofuran / 0.25 h / Ambient temperature

With triethylamine; In tetrahydrofuran; toluene;

Reference yield:

methyl 2-[2-chloro-1-(chloromethyl)ethylidene]-1-hydrazinecarboxylate (87595-89-9) → [3-[Benzyl-(4-chloro-phenyl)-amino]-2-(methoxycarbonyl-hydrazono)-propyl]-phosphonic acid diethyl ester (119592-14-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / toluene / 2 h / Heating

2: Et₃N / tetrahydrofuran / 0.25 h / Ambient temperature

With triethylamine; In tetrahydrofuran; toluene;

upstream raw materials:

hydrazinecarboxylic acid methyl ester

1,3-Dichloroacetone

Downstream raw materials:

N'-[1-Chloromethyl-2-(diphenyl-phosphinoyl)-eth-(E)-ylidene]-hydrazinecarboxylic acid methyl ester

anilino-3 methoxycarbonylhydrazono-2 propylphosphonate de diethyle

[2-(Methoxycarbonyl-hydrazono)-3-(methyl-phenyl-amino)-propyl]-phosphonic acid diethyl ester

[3-(Benzyl-phenyl-amino)-2-(methoxycarbonyl-hydrazono)-propyl]-phosphonic acid diethyl ester

Refernces

• 1、 Jarvis, Amanda G.,Whitwood, Adrian C.,Fairlamb, Ian J. S.. "CuI complexes containing a multidentate and conformationally flexible dibenzylidene acetone ligand (dbathiophos): Application in catalytic alkene cyclopropanation". supporting information; experimental part. p. 3695 - 3702. Retrieved 2011/07/30.
• 2、 Corbel, Bernard,Medinger, Luc,Haelters, Jean Pierre,Sturtz, Georges. "An Efficient Synthesis of Dialkyl 2-Oxoalkanephosphonates and Diphenyl-2-oxoalkylphosphine Oxides from 1-Chloralkyl Ketones". . p. 1048 - 1051. Retrieved 2007/10/02.