2-[4-[2-(benzoxazol-2-ylthio)ethyl]piperazin-1-yl]-N-(2,6-diisopropylphenyl)acetamide

Base Information

Chemical Name:2-[4-[2-(benzoxazol-2-ylthio)ethyl]piperazin-1-yl]-N-(2,6-diisopropylphenyl)acetamide
CAS No.:217093-98-6
Molecular Formula:C₂₇H₃₆N₄O₂S
Molecular Weight:480.674
Hs Code.:

Synonyms:2-[4-[2-(benzoxazol-2-ylthio)ethyl]piperazin-1-yl]-N-(2,6-diisopropylphenyl)acetamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-[4-[2-(benzoxazol-2-ylthio)ethyl]piperazin-1-yl]-N-(2,6-diisopropylphenyl)acetamide

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Technology Process of 2-[4-[2-(benzoxazol-2-ylthio)ethyl]piperazin-1-yl]-N-(2,6-diisopropylphenyl)acetamide

There total 5 articles about 2-[4-[2-(benzoxazol-2-ylthio)ethyl]piperazin-1-yl]-N-(2,6-diisopropylphenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: C₂₁H₃₅N₃O₄S

: 2382-96-9,118090-08-7
2-sulfanyl-1,3-benzoxazole

: 217093-98-6
2-[4-[2-(benzoxazol-2-ylthio)ethyl]piperazin-1-yl]-N-(2,6-diisopropylphenyl)acetamide

Guidance literature:: With 18-crown-6 ether; potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 1h;
DOI:10.1021/acs.jmedchem.8b01256

Reference yield:

: 103-76-4
1-(2-hydroxyethyl)piperazine

: 124-63-0
methanesulfonyl chloride

: 2382-96-9,118090-08-7
2-sulfanyl-1,3-benzoxazole

: 135650-07-6
N-[2,6-bis(1-methylethyl)-phenyl]-2-bromoacetamide

: 217093-98-6
2-[4-[2-(benzoxazol-2-ylthio)ethyl]piperazin-1-yl]-N-(2,6-diisopropylphenyl)acetamide

Guidance literature:: With dmap; sodium chloride; sodium hydrogencarbonate; potassium carbonate; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: N-(2,6-diisopropylphenyl)-2-(4-(2-hydroxyethyl)piperazin-1-yl)acetamide

: 217093-98-6
2-[4-[2-(benzoxazol-2-ylthio)ethyl]piperazin-1-yl]-N-(2,6-diisopropylphenyl)acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine; dmap / tetrahydrofuran / 1 h / 0 °C

2: potassium carbonate; 18-crown-6 ether / N,N-dimethyl-formamide / 1 h / 80 °C

With dmap; 18-crown-6 ether; potassium carbonate; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/acs.jmedchem.8b01256