tert-butyl [1-(4-{2-[6-(4-methoxyphenyl)pyridin-3-yl]-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-3-yl}phenyl)cyclobutyl]carbamate

Base Information

• Chemical Name: tert-butyl [1-(4-{2-[6-(4-methoxyphenyl)pyridin-3-yl]-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-3-yl}phenyl)cyclobutyl]carbamate
• CAS No.: 1374263-54-3
• Molecular Formula: C₄₁H₃₈N₆O₃
• Molecular Weight: 662.791
• Mol file: 1374263-54-3.mol

Synonyms:tert-butyl [1-(4-{2-[6-(4-methoxyphenyl)pyridin-3-yl]-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-3-yl}phenyl)cyclobutyl]carbamate

Chemical Property of tert-butyl [1-(4-{2-[6-(4-methoxyphenyl)pyridin-3-yl]-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-3-yl}phenyl)cyclobutyl]carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl [1-(4-{2-[6-(4-methoxyphenyl)pyridin-3-yl]-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-3-yl}phenyl)cyclobutyl]carbamate

There total 10 articles about tert-butyl [1-(4-{2-[6-(4-methoxyphenyl)pyridin-3-yl]-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-3-yl}phenyl)cyclobutyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(4-methoxyphenyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (1374263-53-2) + tert-butyl {1-[4-(2-bromo-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-3-yl)phenyl]cyclobutyl}carbamate (1374260-87-3) → tert-butyl [1-(4-{2-[6-(4-methoxyphenyl)pyridin-3-yl]-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-3-yl}phenyl)cyclobutyl]carbamate (1374263-54-3)

Guidance literature:

With bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); sodium carbonate; In water; N,N-dimethyl-formamide; at 160 ℃; for 1h; Microwave irradiation;

Reference yield:

5-bromo-2-(4-methyloxyphenyl)pyridine (88345-93-1) → tert-butyl [1-(4-{2-[6-(4-methoxyphenyl)pyridin-3-yl]-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-3-yl}phenyl)cyclobutyl]carbamate (1374263-54-3)

Guidance literature:

Multi-step reaction with 2 steps

1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / 1,4-dioxane / 65.5 h / 80 °C

2: bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); sodium carbonate / water; N,N-dimethyl-formamide / 1 h / 160 °C / Microwave irradiation

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); potassium acetate; sodium carbonate; In 1,4-dioxane; water; N,N-dimethyl-formamide;

Reference yield:

4-methoxyphenylboronic acid (5720-07-0) → tert-butyl [1-(4-{2-[6-(4-methoxyphenyl)pyridin-3-yl]-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-3-yl}phenyl)cyclobutyl]carbamate (1374263-54-3)

Guidance literature:

Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water; toluene / 40.5 h / 80 °C / Inert atmosphere

2: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / 1,4-dioxane / 65.5 h / 80 °C

3: bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); sodium carbonate / water; N,N-dimethyl-formamide / 1 h / 160 °C / Microwave irradiation

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); potassium acetate; sodium carbonate; In 1,4-dioxane; water; N,N-dimethyl-formamide; toluene;

upstream raw materials:

4-methoxyphenylboronic acid

2-iodo-5-bromopyridine

5-bromo-2-(4-methyloxyphenyl)pyridine

5H-benzo[e]pyrido[3,2-b][1,4]diazepin-6(11H)-one