Technology Process of tert-butyl 4-(4-{(5S)-5-[(acetyl amino)methyl]-2-oxo-1,3-oxazolidin-3-yl}-2-fluorophenoxy)piperidine-1-carboxylate
There total 10 articles about tert-butyl 4-(4-{(5S)-5-[(acetyl amino)methyl]-2-oxo-1,3-oxazolidin-3-yl}-2-fluorophenoxy)piperidine-1-carboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: 89 percent / KOtBu / tetrahydrofuran / 0 - 20 °C
2.1: ammonium formate / 10 percent Pd/C / methanol / 2 h / Heating
3.1: 2.06 g / NaHCO3 / acetone; H2O / 6 h / 20 °C
4.1: n-BuLi / tetrahydrofuran / 1 h / -78 °C
4.2: 72 percent / tetrahydrofuran / -78 - 20 °C
5.1: triethylamine / CH2Cl2 / 3 h / 0 °C
6.1: 2.07 g / sodium azide / dimethylformamide / 75 °C
7.1: triphenylphosphine / tetrahydrofuran / 3 h / 20 °C
7.2: H2O / 4 h / 60 °C
8.1: 1.85 g / pyridine / ethyl acetate / 20 °C
With
pyridine; n-butyllithium; sodium azide; potassium tert-butylate; ammonium formate; sodium hydrogencarbonate; triethylamine; triphenylphosphine;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetone;
DOI:10.1016/S0968-0896(02)00065-2
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: 89 percent / KOtBu / tetrahydrofuran / 0 - 20 °C
2.1: ammonium formate / 10 percent Pd/C / methanol / 2 h / Heating
3.1: 2.06 g / NaHCO3 / acetone; H2O / 6 h / 20 °C
4.1: n-BuLi / tetrahydrofuran / 1 h / -78 °C
4.2: 72 percent / tetrahydrofuran / -78 - 20 °C
5.1: triethylamine / CH2Cl2 / 3 h / 0 °C
6.1: 2.07 g / sodium azide / dimethylformamide / 75 °C
7.1: triphenylphosphine / tetrahydrofuran / 3 h / 20 °C
7.2: H2O / 4 h / 60 °C
8.1: 1.85 g / pyridine / ethyl acetate / 20 °C
With
pyridine; n-butyllithium; sodium azide; potassium tert-butylate; ammonium formate; sodium hydrogencarbonate; triethylamine; triphenylphosphine;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetone;
DOI:10.1016/S0968-0896(02)00065-2
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: ammonium formate / 10 percent Pd/C / methanol / 2 h / Heating
2.1: 2.06 g / NaHCO3 / acetone; H2O / 6 h / 20 °C
3.1: n-BuLi / tetrahydrofuran / 1 h / -78 °C
3.2: 72 percent / tetrahydrofuran / -78 - 20 °C
4.1: triethylamine / CH2Cl2 / 3 h / 0 °C
5.1: 2.07 g / sodium azide / dimethylformamide / 75 °C
6.1: triphenylphosphine / tetrahydrofuran / 3 h / 20 °C
6.2: H2O / 4 h / 60 °C
7.1: 1.85 g / pyridine / ethyl acetate / 20 °C
With
pyridine; n-butyllithium; sodium azide; ammonium formate; sodium hydrogencarbonate; triethylamine; triphenylphosphine;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetone;
DOI:10.1016/S0968-0896(02)00065-2
